Endoscopic submucosal dissection (ESD) is an effective strategy for complete resection of superficial esophageal neoplasia. However, such lesions in patients with cirrhosis and portal hypertension

Cold snare polypectomy of colorectal polyps sometimes leaves a cord of white tissue consisting of submucosa and, sometimes, muscularis mucosa. These defects are called “cold

Sedation practice for endoscopy varies widely in the United States. One model is to use anesthesia specialists to administer propofol for complex endoscopic procedures, such

Managing choledocholithiasis in patients after Roux-en-Y gastrectomy is challenging, and with no excluded stomach, endoscopic ultrasound (EUS)-guided transmural lumen-apposing metal stent placement is significantly more

The treatment of type 2 diabetes has evolved over the past decade, and incretin-based drugs, including dipeptidyl peptidase 4 (DPP4) inhibitors and glucagon-like peptide-1 (GLP-1)

This study utilized data from two cohorts of the Nurses’ Health Study involving nearly 159,000 women and 3.5 million person-years of follow-up. The investigators discovered

Among 2629 large nonpedunculated colorectal polyps in 2350 patients, 10 were classified as anastomotic and had a median lesion size of 35 mm. All lesions

The prevalence of GERD after peroral endoscopic myotomy (POEM) ranges from 13% to 58%. This variation is due to a lack of precise definitions and

Endoscopy plays a significant role in a gastroenterologist’s practice. Unindicated or inappropriate endoscopies increase costs, take away resources from other patients, and may have a

About 15% of large (≥20 mm) nonpedunculated colorectal polyps (LNPCPs) removed by piecemeal endoscopic mucosal resection (EMR) have evidence of recurrence at the first endoscopic

Texture and color enhancement imaging (TXI) is a new image-processing feature on the latest generation of Olympus colonoscopes (Tokyo, Japan). These instruments have been commercially

Peutz-Jeghers syndrome (PJS) and juvenile polyposis syndrome (JPS) are hamartomatous polyposis syndromes associated with increased cancer risk. The Danish national health registries systematically record health

Previous studies have shown that most patients who had not undergone colorectal cancer (CRC) screening reportedly had not been offered screening by their primary care

Peroral endoscopic myotomy (POEM) is a standard treatment option for patients with achalasia but is associated with a high incidence of postprocedure gastroesophageal reflux disease

Choledocholithiasis can be identified through multiple means, including a right upper quadrant ultrasound, endoscopic ultrasound (EUS), endoscopic retrograde cholangiography (ERCP), magnetic resonance cholangiopancreatography (MRCP), and

For patients with intramucosal esophageal adenocarcinoma (T1a EAC), endoscopic treatment (endoscopic resection, followed by ablation) is the current standard. This study focused on patients with

Most randomized controlled trials (RCTs) of computer-aided detection (CADe) demonstrate increased detection, but some RCTs and real-world experiences with CADe have failed to show a

Serrated polyposis syndrome (SPS) is the most common type of polyposis syndrome, affecting as many as one in every 250 persons undergoing screening colonoscopy. It

Traditionally, malignant biliary obstruction is relieved by placing a transpapillary stent during endoscopic retrograde cholangioscopy (ERCP). Pancreatitis is a possible adverse event of ERCP. Additionally,

The value of colorectal cancer (CRC) screening lies in CRC prevention through polyp detection and prevention of CRC mortality by early-stage CRC detection. Compared with

These data are from a population-based Chinese screening program involving 595,180 persons aged 40 to 74 years with 16 years of follow-up. There were 42,353

Twenty-five studies with 30 interventions were analyzed for this study on the effect of behavioral interventions on colonoscopy uptake. Of the interventions evaluated by the

Previous research has suggested a potential connection between proton pump inhibitors (PPIs) and a higher risk of dementia, causing concern among patients and health care

Previous research has suggested a potential connection between proton pump inhibitors (PPIs) and a higher risk of dementia, causing concern among patients and health care

Current recommended postpolypectomy surveillance intervals for patients with serrated lesions are based on limited evidence. This single-center study evaluated risk factors for metachronous advanced serrated

Laparoscopic fundoplication (LF) as a treatment option for GERD involves 3 techniques based on the wrap extension: Nissen (total, 360°), Toupet (posterior, 270°), and Dor

Thermal injury from biliary sphincterotomy is thought to play a role in at least a proportion of post-ERCP pancreatitis (PEP) cases. Thus, the present study

Among the key and newer points from a recent review on the best performance of basic colonoscopy, including the resection of lesions <20 mm in

Over-the-scope suturing (OTSS) requires a double-channel gastroscope, and closure of defects in the right side of the colon may require an overtube. Through-the-scope suturing (TTSS)

Presently, there is no specific drug recommendation as the preferred treatment for active eosinophilic esophagitis (EoE) nor clear guidance on the comparative effectiveness of various

This is a single, blind, multicenter, randomized, controlled trial that compared oral sulfate solution (OSS) to a sports drink-like flavored solution of polyethylene glycol and

In patients with GERD, there is a need to understand the poor symptom-reflux association and the potential role of psychological processes in reporting esophageal symptom

Daily intake of low-dose aspirin increases the risk of major bleeding, but its effect on iron deficiency and anemia is less studied. This study, a

The current standard method for diagnosing and staging esophageal subepithelial lesions and tumors is endoscopic ultrasound (EUS). This study focused on a newly developed medical

Single-use duodenoscopes were developed to eliminate the risk of duodenoscope-associated transmission of infections. However, there are concerns that the performance of single-use duodenoscopes may not

There is agreement that endoscopic full-thickness resection (EFTR) is a great procedure for lesions extending into the appendiceal orifice (AO) when there has been a

In a cross-sectional retrospective study at a single U.S. health care system, colonoscopic findings of 150 randomly selected patients with early-onset colorectal cancer (CRC) were

Increasingly, we are consulted on or asked to perform colonoscopies on patients who previously underwent multigene panel testing for oncogenes associated with colorectal cancer (CRC).

Dealing with esophageal food bolus impactions (FBIs) is a frequent gastrointestinal emergency. Effective handling of esophageal FBIs entails promptly conducting an endoscopic assessment and addressing

Recent studies have found that significant fractions of colonoscopists possess adequate detection of conventional adenomas, as measured by adenoma detection rate (ADR), but low detection

The serrated pathway of colorectal cancer (CRC) is considered to account for about 20% of all CRCs. Patients with serrated polyposis syndrome (SPS) have higher

The U.S. Multi-Society Task Force on Colorectal Cancer recommends that polyps ≥1 cm be photographed before resection to document size and the resection site photographed

Tip-in endoscopic mucosal resection (T-EMR) involves submucosal injection, followed by a small incision into the submucosal mound on the cecal side of the lesion. The

This systematic review and meta-analysis identified 6 studies with 1025 patients and 1111 polyps with a mean size ranging from 4 to 8.5 mm. Cold

Given reports on the rising global incidence and prevalence of eosinophilic esophagitis (EoE) and the associated societal impact, investigators conducted a systematic review and meta-analysis

In addition to dietary modification and pharmacologic therapy, behavioral therapy has become a recognized treatment for irritable bowel syndrome (IBS) and is now integrated into

Sleeve gastrectomy (SG) has become a popular choice for weight loss due to its ease and effectiveness. However, it can worsen symptoms of esophageal reflux

It is known that some patients with head and neck squamous cell carcinoma (HNSCC) can develop a second primary tumor (SPT). Timely detection of SPTs

Same-admission cholecystectomy is recommended for patients with mild gallstone pancreatitis (GSP) to reduce recurrent GSP events and lower costs. However, adherence to same-admission cholecystectomy remains

Underwater endoscopic submucosal dissection (U-ESD; typically performed with saline rather than water) has several potential advantages over conventional ESD (C-ESD; performed with carbon dioxide insufflation).

Treating bleeding malignant tumors is challenging because they tend to be diffusely friable. Hemostatic powder is a relatively new tool in the endoscopic armamentarium for

This study used SEER (Surveillance, Epidemiology, and End Results) data to update colorectal cancer (CRC) incidence and mortality trends from 1992 to 2019. The well-known

Cold snare polypectomy (CSP) is the preferred resection method for colorectal lesions ≤10 mm. Competence in CSP can be assessed using the CSPAT (Cold Snare

Diagnosis and resection of subcentimeter subepithelial tumors (SETs) can be challenging. One problem with endoscopic band ligation (EBL) and allowing the lesion to slough is

Those performing endoscopic mucosal resection (EMR) in the colorectum should be aware of this remarkably comprehensive document from the European Society of Gastrointestinal Endoscopy that

ERCP is a vital endoscopic procedure for the management of pancreatobiliary disease but is associated with serious adverse events, including mortality. Although a central tenet

ERCP is generally the first-line approach for palliation of distal malignant biliary obstruction (DMBO), but interest in the use of endoscopic ultrasound (EUS)-guided transmural drainage

Current recommendations suggest measuring the adenoma detection rate (ADR) in first-time screening colonoscopies. Several studies have found that including surveillance and diagnostic colonoscopies in an

It is clear that metal stents are superior to plastic stents for palliation of distal malignant biliary obstruction (dMBO). Among self-expanding metal stents (SEMS), there

This study looked at retained tissue in the endoscope after EGD and colonoscopy in which only cold forceps biopsies were performed. The study cases were

Very large specimens obtained by endoscopic submucosal dissection may fragment during retrieval through the anus. The Endo Carry Large Type (Hakko Co, Tokyo, Japan) is

Cold snare resection is the treatment of choice for 4- to 9-mm polyps, yet some practitioners perform submucosal injection for polyps in this size range.

In some countries, pathologists and pathology departments are overworked. A number of artificial intelligence (AI) programs have shown substantial accuracy in interpretation of whole slide

This study examined the quality of answers provided by ChatGPT (OpenAI, San Francisco, Calif) to 8 common questions about colonoscopy, compared with answers to the

Cancer incidence studies in national registries, such as that maintained in Denmark, are of interest because they reduce referral bias. A study used nationwide Danish

Helicobacter pylori eradication has been shown to decrease the risk of noncardia gastric adenocarcinoma (NCGA) in Asia; however, the data in the United States are limited.

For the treatment of patients with achalasia, peroral endoscopic myotomy (POEM) has shown comparable effectiveness to surgery. During POEM, the typical length of the myotomy

Natural language processing (NLP) is a computer technology that uses language cues and context to interpret findings and mine large databases to identify desired clinical

According to data, 1.5% of the U.S. population has hereditary breast and ovarian cancer syndrome (0.72%), Lynch syndrome (0.35%), or familial hypercholesterolemia (FH; 0.43%). This

Water instillation is now commonly used for a variety of purposes during colonoscopy. Water filling during colonoscope insertion has been shown to decrease pain, reduce

Palliation of malignant biliary obstruction is required to facilitate oncologic therapy and relief of symptoms. Although this is almost always performed with ERCP, biliary cannulation

Data directly comparing treatment options for achalasia are limited, namely peroral endoscopic myotomy (POEM), laparoscopic Heller myotomy (LHM), and endoscopic pneumatic dilation (PD). The current

Patients with advanced or high-risk adenomas are recommended to undergo surveillance earlier than patients with low-risk adenomas. In the U.S., the traditional high-risk group classification

In a systematic review and meta-analysis, 15 studies evaluating the impact of report cards on adenoma detection rate (ADR) were among the 34 studies that

Birth by cesarean delivery has been associated with intestinal dysbiosis in childhood. This study is a population-based, nationwide, case-control study from Sweden involving 564 cases

Malignant gastric outlet obstruction (mGOO) results in significant morbidity and decreased quality of life. Treatment options include surgical gastrojejunostomy (SGJ) and endoscopic ultrasound-guided gastroenterostomy (EUS-GE).

Adequate patient sedation is essential for the successful completion of ERCP; however, delivery methods of anesthesia vary between providers, with most endoscopists favoring deep sedation

The Index of Severity for EoE (I-SEE) is a new tool created by a multidisciplinary team to identify meaningful features of eosinophilic esophagitis (EoE) disease

Long-term exposure to PM2.5 (fine particulate matter) is a known risk factor for lung cancer. However, the evidence linking PM2.5 to esophageal cancer is sparse

In a prospective study from Singapore, the computer-aided diagnosis (CADx) program CAD EYE (Fujifilm, Tokyo, Japan) was assessed in 661 consecutive polyps of all sizes

This study from the Northern California Kaiser Permanente health care system evaluated the impact of a 30-minute online interactive training program collaboratively developed by endoscopists,

In a randomized trial, 1316 patients underwent colonoscopy with either computer-aided detection (CADe) assistance alone or CADe plus Endocuff Vision (ECV; Olympus America, Center Valley,

In a Japanese experience of endoscopic submucosal dissection (ESD) performed on 483 rectal lesions over 23 years, a prolonged ESD was considered longer than 120

Local triamcinolone (TA) therapy involves injecting approximately a 100-mg dose of TA into the ulcer immediately after an endoscopic submucosal dissection procedure to reduce the

Endoscopic closure techniques are essential for successful closure of resection sites and acute perforations. Initially largely limited to through-the-scope (TTS) clips, the armamentarium has evolved

This study used the World Endoscopy Organization classification of postcolonoscopy colorectal cancer (PCCRC) to assess 762 PCCRC cases that accumulated during 1995 to 2021. PCCRC

Adenomas are commonly diagnosed in patients younger than age 50 undergoing colonoscopy. Adenomas in young people often initiate surveillance at shorter than the recommended intervals,

This was a randomized controlled trial in 359 veterans aged 50 to 75 years who had declined colonoscopy and a fecal immunochemical test (FIT) in

Successful and safe ERCP requires the endoscopist to cannulate the duct of interest successfully and efficiently. Although operator skill clearly influences procedure success, there is

The U.S. Preventive Services Task Force recommends that the decision regarding whether to screen persons aged 75 to 85 years for colorectal cancer be individualized

Experienced endoscopists are aware that the mucosa on the ileocecal valve (ICV) lips has a 3- to 10-mm-wide transition zone between normal colonic mucosa and

In a study of 29,877 patients with colorectal cancer (CRC) in the U.S. Veterans Affairs (VA) health care system, the rate of postcolonoscopy colorectal cancer

Endoscopic resection (ER) plays a critical role in both treating and diagnosing superficial esophageal cancer. However, the incidence of lymph node metastasis in patients with

ERCP and EUS are essential in treating a variety of disease entities. Metrics exist to measure performance quality, but data are necessary to improve quality

Peroral endoscopic myotomy (POEM) is increasingly being used as mainline therapy for patients with achalasia. After POEM, approximately 30% to 50% of patients experience abnormal

Cold snare polypectomy is now the resection method of choice for colorectal lesions ≤10 mm in size. The risk of resecting a cancerous lesion in

Endoscopic submucosal dissection (ESD) is an option for scarred, large colorectal adenomas that do not lift well and/or contain a suspicious area of an advanced

Pancreatitis after ERCP is one of the most common and morbid adverse events following any gastrointestinal endoscopy procedure. It is imperative that the consent process

In 3 U.S. centers, asymptomatic patients aged 50 to 69 years (or 40-69 if Black) were randomized to screening colonoscopy or annual sequential high-sensitivity guaiac

The development of hemostatic powders has increased the tools in our armamentarium to treat GI bleeding. However, data on their utility in peptic ulcer bleeding

Research into peroral endoscopic myotomy (POEM) as a rescue therapy for patients with persistent or recurrent symptoms after laparoscopic Heller myotomy (LHM) is increasing. Although

The current screening model for Barrett’s esophagus (BE) has limitations because patients need to be identified by their primary care physician and then referred to

The overwhelming majority of randomized trials testing the impact of computer-aided detection (CADe) programs have shown substantial benefits. In a randomized controlled trial in 4

There are several elimination diet regimens available, including the 6-food elimination diet (SFED), 4-food elimination diet (FFED), one-food elimination diet (OFED), and targeted elimination diet

An expert colonoscopist recommends the following for photography during colonoscopy:  Cecal landmarks Terminal ileum, if intubated Bowel preparation quality Large lesions before and after endoscopic

Colonoscopists are advised to consider age, comorbidities, and colonoscopy findings before recommending surveillance. In a study of the New Hampshire Colonoscopy Registry, 9831 adults older

X-Tack (Apollo Endosurgery, Austin, Texas) is a through-the-scope suturing device that can be an alternative to through-the-scope clips. No controlled trial of X-Tack versus clips

Cold snare polypectomy is now widely accepted as the treatment of choice for colorectal polyps 4 to 10 mm in size. Despite overwhelming evidence that

Randomized controlled trials (RCTs) have generally shown consistent improvements in adenoma detection rates (ADRs) with the use of computer-aided detection (CADe) during colonoscopy, but a

Colonoscopy is often recommended after an episode of acute diverticulitis, particularly complicated diverticulitis, and when no colonoscopy was performed the previous year. Colonoscopy in prior

Some previous work has suggested that the prevalence of advanced lesions in the appendix is high enough to warrant routine appendectomy in patients with serrated

Some studies suggest that prior treatment may increase the difficulty and success of tunneling during a peroral endoscopic myotomy (POEM) procedure, but recent studies have

Malignant gastric outlet obstruction (GOO) has a profound negative impact on quality of life (QoL). Options for palliation include surgical gastroenterostomy, enteral stent placement, and,

Upper gastrointestinal cancers (UGICs) are typically diagnosed through endoscopy, but some cases may be missed and diagnosed later, known as postendoscopy UGICs (PEUGICs). PEUGICs are

Esophagogastroduodenoscopy (EGD) requires clear visualization of the upper gastrointestinal (UGI) mucosa, but there is no standardized method to assess mucosal visualization. Lesions are often missed

In this retrospective study from Japan, researchers compared delayed bleeding rates for 82 patients who underwent ESD while continuing antithrombotic medications versus 386 patients without

Endoscopic surveillance of Barrett’s esophagus (BE) is recommended to reduce mortality and morbidity related to esophageal adenocarcinoma. A thorough endoscopic inspection of a BE segment

Large (≥20 mm) colorectal lesions are often accompanied by synchronous lesions, including a high prevalence of synchronous advanced lesions. This study examined the relationship between

Patients with colorectal cancer (CRC) metastatic to the liver or lung often do not undergo surgical resection of their primary tumor. However, the primary tumor

In 2016, motorized spiral enteroscopy (mSe) was introduced to facilitate visualization for diagnosis and therapy of the small bowel. The primary aim of this review

Cold snare polypectomy is the accepted treatment of choice for all colorectal polyps smaller than 10 mm and with no suggestion of cancer on endoscopic

Lynch syndrome is caused by germline mutations in MLH1, MSH2, MSH6, or PMS2 genes, but the most commonly affected genes are MLH1 and MSH2. Increasingly, surveillance recommendations are on a gene-specific basis, with

Endoscopic submucosal dissection (ESD) is frequently followed by hospital admission for multiple days in Asian countries. However, hospitalization is much more expensive in the U.S.,

In an observational study of colorectal EMR, 67 of 336 patients (19.9%) experienced postprocedural pain. All EMRs were performed with electrocautery and adrenaline injection. Pain

In a very large study, 11.8% of 77,007 patients receiving antithrombotic treatment had a positive fecal immunochemical test (FIT) result, compared with 6% of those

In patients with esophageal squamous cell carcinoma with invasion into the muscularis mucosa (pMM-ESCC) with lymphovascular invasion (LVI), the Japan Esophageal Society recommends additional treatment

Resection of duodenal adenomas (DAs) can be challenging, in part due to the thinness of the duodenal wall and its vascularity. Both postprocedural bleeding (PPB)

Traditionally, even if careful inspection of an EMR scar at follow-up shows no residual polyp, a biopsy should still be performed to rule out histologic

Although there are rules for when to stop colorectal cancer screening, there are no rules about when to stop surveillance colonoscopy in patients with precancerous

Case-control studies and cohort studies have found that colonoscopy prevents colorectal cancer (CRC) for 15 to 20 years or more. However, only a few small

It is well known that the rates of follow-up colonoscopy after a positive fecal screening test are suboptimal, and delays in colonoscopy versus prompt colonoscopy

This study used eye tracking of 7 endoscopy trainees to determine whether missed polyps had not been seen versus seen but not recognized.  Trainees identified

Per the Lyon Consensus, endoscopic documentation of Los Angeles (LA) grade C or D esophagitis is conclusive evidence of GERD, whereas LA grades A and

Eosinophilic esophagitis (EoE) is a chronic condition increasingly encountered in clinical practice. The establishment of quality indicators (QIs) in EoE will lead to the standardization

This study describes the prospective testing of a computer-aided diagnosis (CADx) system called POLyp Artificial Recognition (POLAR), developed for real-time diagnosis of diminutive colorectal polyps.

This systematic review and meta-analysis identified 22 studies from 3 continents that addressed the risk of colorectal cancer (CRC) after appendectomy in the general population.

Chronic opioid use can lead to a variety of esophageal disorders, including type III achalasia, esophagogastric outflow obstruction (EGJOO), diffuse esophageal spasm (DES), and hypercontractile

Eosinophilic gastrointestinal diseases (EGIDs) are rare inflammatory conditions of the GI tract characterized by tissue eosinophilia and chronic GI symptoms. EGIDs include eosinophilic gastritis (EoG)

This study examined the positive predictive value (PPV) of a second round of screening with a fecal immunochemical test (FIT)-fecal DNA test (Cologuard, Exact Sciences).

This report is from the National Health Interview Survey, an annual survey of U.S. households covering a wide range of health topics. Response rates were

In a study from China, 548 patients were randomized to receive 2 L of polyethylene glycol (PEG) on the day of colonoscopy or 290 µg

Barrett’s esophagus (BE)-related neoplasia is frequently missed during upper endoscopy, and characterization of mucosal changes may help in its detection. The primary aim of this

Increasingly, antibiotics are used to treat acute uncomplicated appendicitis. Successful antibiotic treatment can be followed by recurrence. An alternative nonoperative approach is endoscopic retrograde appendicitis

Many experts now routinely examine the proximal colon twice because colonoscopy is less protective against colorectal cancer in the proximal colon than in the distal

Tissue sampling of subepithelial lesions (SELs) is needed to determine the diagnosis, malignant potential, and management of these lesions. Endoscopic ultrasound-guided fine needle aspiration and/or

Subtle surface changes associated with early-stage esophageal squamous cell cancer (ESCC) can be difficult to detect during standard endoscopy. The primary aim of this study

Computer-aided detection (CADe) programs are expensive to implement in clinical practice; therefore, endoscopy groups often want to trial the programs before purchase or lease. In

Artificial intelligence programs for highlighting or detecting polyps during colonoscopy are designated computer-aided detection (CADe) programs. In general, randomized controlled trials of CADe have been

Bleeding can be problematic during endoscopic submucosal dissection (ESD). The bleeding point may be difficult to identify, and coagulation may lead to muscle injury and

This study assessed 94 randomized controlled trials with 61,172 patients to determine how artificial intelligence (AI) impacts the adenoma detection rate (ADR). In short, AI

Current treatment options for patients with eosinophilic esophagitis (EoE) include the use of topical corticosteroids. This study aimed to demonstrate whether outcomes of topical corticosteroids

The fecal immunochemical test (FIT) is a simple, noninvasive, at-home study that detects blood in the stool and is used for colon cancer (CRC) screening

Postcolonoscopy colorectal cancer (PCCRC) is a dreaded event. Previous studies have found that PCCRC is associated with a lower adenoma detection rate (ADR), nongastroenterologist performance

Endoscopic mucosal resection (EMR) is the cornerstone of the treatment of large (≥20 mm) nonpedunculated colorectal lesions. This study from a Canadian expert center examined

Nonampullary adenomas are frequently associated with an increased risk of colorectal adenomas. There is less known about the association between ampullary adenomas and colorectal neoplasia.

Although small (<2 cm), nonfunctioning pancreatic neuroendocrine tumors (PNETs) are typically followed, there are instances, such as patient anxiety, that prompt resection. Endoscopic ultrasound-guided ethanol

Atypical GERD symptoms, including cough and hoarseness, can be difficult to treat, even with proton pump inhibitors and laparoscopic surgical fundoplication. Transoral incisionless fundoplication (TIF),

Barrett’s esophagus (BE) is a precancerous condition that can lead to the development of dysplasia and esophageal adenocarcinoma (neoplasia). Since neoplasia can present as subtle

Cold snare is now considered the polypectomy method of choice for polyps <10 mm in size, and recent studies have extended the use of cold

Patients taking direct oral anticoagulants (DOACs) are often considered to be at increased risk for bleeding after therapeutic endoscopic procedures such as polypectomy and sphincterotomy. 

This study updates complication rates associated with the full-thickness resection device (FTRD) from a combined Dutch and German registry, with 1892 procedures performed between July

High-risk Stage I Esophageal Cancer Traditionally, surgical resection has been the standard for the treatment of patients with clinical stage I T1a-bN0M0 esophageal squamous cell

Genome-wide association studies (GWAS) involve scanning the DNA of a large cohort to identify any genetic variants associated with the disease in question. Previous GWAS

Previous studies have found that patients with large (≥20 mm) nonpedunculated colorectal polyps have a high prevalence of synchronous colorectal neoplasia. This study investigated synchronous

Previous studies have found yoga as effective as other treatments for irritable bowel syndrome (IBS) symptoms. This study tested whether virtually delivered yoga improved IBS

This study evaluated 3766 patients with colon cancer in the U.K., of whom 16.5% had preexisting mental health morbidities (MHMs) recorded in their primary care

Cholecystitis following biliary drainage with a self-expandable metallic stent (SEMS) in patients with distal malignant biliary obstruction (MBO) and cystic duct orifice involvement is significant.

Endoscopic resection is a minimally invasive and curative treatment option for those with superficial esophageal squamous cell carcinoma (ESCC). Endoscopic submucosal dissection (ESD), although more

Ideally, patients presenting for colonoscopy should have a complete examination and identification and resection of all precancerous polyps in a well-prepared colon, followed by assignment

Metabolic syndrome (MS), diabetes mellitus, and obesity are all associated with an increased prevalence of precancerous colorectal polyps and incidence of colorectal cancer (CRC). This

Thermal treatment of endoscopic mucosal resection (EMR) margin defects after complete resection of large (≥20 mm) nonpedunculated colorectal polyps has reduced the recurrence rate at

Erosive esophagitis, a complication of chronic gastroesophageal reflux disease (GERD), is documented in 30% to 50% of GERD patients undergoing endoscopy. Current guidelines recommend proton

As a subspecialty, GI medicine is typically ranked in the top 3 for its high carbon footprint and production of plastic waste. The 4 U.S. GI

In a randomized controlled trial (RCT) performed in Brazil, 120 colorectal lesions with a mean size of 17.5 mm were randomized to underwater endoscopic mucosal

Investigators evaluated 30,897 individuals with baseline polypectomy and at least 1 surveillance colonoscopy between 2004 and 2016 across 73 Veterans Administration sites in the U.S.,

Thermal treatment of the margin after piecemeal endoscopic mucosal resection (EMR) of laterally spreading lesions (LSLs) ≥20 mm is now considered standard of care because

A significant portion of patients with reflux-like symptoms do not have GERD and could potentially discontinue proton pump inhibitor (PPI) therapy. Although wireless pH monitoring

Juvenile polyposis syndrome (JPS), in which patients develop juvenile polyps, is uncommon but is thought to be associated with an increased risk of gastrointestinal cancers.

This is a survey of 5134 patients who participated in a telehealth visit in 1 year across 105 practices in the Digestive Health Physicians Association. 

This study divided 656 participants with stage IV colorectal cancer (CRC) into groups according to their prediagnosis body mass index (BMI): normal (38.3%), overweight (36.3%),

Current recommendations are that minimum withdrawal times in screening colonoscopy that are negative should average at least 6 minutes.  In an analysis of a previously

The European Society of Gastrointestinal Endoscopy has released updated recommendations on the diagnosis and management of esophagogastric variceal hemorrhage. Of the 16 recommendations, all are

In a randomized controlled trial, 1245 participants aged 50 to 75 years were randomized to standard colonoscopy, standard colonoscopy plus an artificial intelligence (AI) detection

In a randomized tandem study from China, 2 study arms compared the standard colonoscopy withdrawal time of 6 minutes versus 9 minutes. The colon was

Traditional serrated adenomas (TSAs) are rare lesions. They are predominantly in the left side of the colon, and unlike sessile serrated lesions, they can be

This is a pooled analysis of 4 randomized controlled trials of one-time sigmoidoscopy screening in patients aged 55 to 64 years. The trials were conducted

Eosinophilic esophagitis (EoE) is influenced by both genetic and environmental factors. The genetic risk of distal eosinophilic gastrointestinal diseases in patients with EoE is not

It is well known that the prevalence of adenomas is higher in patients with a positive result from a stool test, including both the fecal

Cancer screening can lead to patient-level harms from screening tests, diagnostic follow-up, and cancer treatment. This review examined U.S. screening guidelines on breast, cervical, colorectal,

In a study of the National Cancer Database, the distance of patients from their medical facility was found to be associated with a risk of

The Centers for Disease Control and Prevention (CDC) quantifies social vulnerability in the U.S. at the county level. The Social Vulnerability Index (SVI) reflects infrastructure,

This is a subinvestigation of a randomized bowel preparation trial in 10 Canadian centers. Patients were divided into 2 groups and underwent colonoscopy either in

Gastroenterologists commonly evaluate unexplained chronic or recurrent abdominal pain. In a review of overlooked causes of recurrent abdominal pain, some key points were: Chronic abdominal

This systematic review and meta-analysis identified 13 qualitative studies of the accuracy of GI endoscopist self-assessment and 3 studies for individual patient data meta-analysis. These

Natural language processing (NLP) is a branch of artificial intelligence (AI) systems that involves teaching computers the ability to understand written text like how humans

In the first report of incidence and mortality results from a randomized controlled trial (RCT) comparing colonoscopy with no screening, 84,585 previously unscreened persons aged

This study looked at reimbursement from Medicare for 10 commonly used EGD and colonoscopy codes as well as several inpatient and outpatient services over a

Recent studies have demonstrated that dietary elimination therapy is an effective nonprescription treatment for eosinophilic esophagitis (EoE), yet many providers are still hesitant about recommending

Refractory celiac disease (RCD) is defined as celiac disease with persistent symptoms despite at least 12 months of a strict gluten-free diet. There are 2

There are few prospective, detailed studies on factors such as time lost from work and symptoms after colonoscopy. This study prospectively measured postcolonoscopy symptoms in

In 2014, the Netherlands instituted a national program of every-other-year fecal immunochemical test (FIT) screening for colorectal cancer (CRC). Since the start of screening, within

One treatment method for patients with eosinophilic esophagitis (EoE) is the six-food elimination diet (SFED), which removes milk, wheat, soy, egg, tree nuts/peanuts, and fish/shellfish

This is a post hoc analysis of a risk-stratification screening strategy based on the Asia-Pacific Colorectal Screening (APCS) scoring system. This score ranks patients as

CDH1 mutations are associated with a very high risk of gastric cancer, early age of onset of gastric cancer, and a high risk of breast cancer

Endoscopic therapy for patients with neoplastic Barrett’s esophagus (BE) involves resection followed by mucosal ablation. Radiofrequency ablation (RFA) of the flat BE mucosa leads to

Data on colorectal cancer (CRC) incidence and deaths were extracted from the GLOBOCAN database for 2020, and projections were made for 2040. Some of the

Although dietary changes are recommended for patients with gastroesophageal reflux disease (GERD), randomized controlled trials (RCTs) supporting these management strategies are lacking. This RCT evaluated

It is well-known that some clustering of adenomas occurs in the colorectum. In a single-center study in patients each with a single index adenoma, 61%

The second-generation Endocuff (Olympus America, Center Valley, Penn, USA) is called Endocuff Vision (ECV). It differs from the original Endocuff by having only a single

The U.S. Multi-Society Task Force on Colorectal Cancer (USMSTF) creates postpolypectomy surveillance interval recommendations for the U.S. The main change to the 2020 guideline was

This study examined the fraction of patients undergoing colonoscopy with versus without artificial intelligence (AI) in 9 randomized controlled trials (6 parallel and 3 tandem)

In an article published by Gastrointestinal Endoscopy in its new Top Tips section, Shaukat reviews methods to improve bowel preparation in the endoscopy unit: Map the bowel

Current strategies for the endoscopic treatment of Barrett’s esophagus (BE) focus on resection of nodular lesions within BE and then the ablation of the flat

Previous studies have found that interval or postcolonoscopy cancers have molecular profiles that differ somewhat from those of cancers detected at a baseline colonoscopy, including

Current recommendations for sporadic colorectal cancer (CRC) are to perform surveillance colonoscopy 1 year after surgical resection, then at 3 years, and then at 5-year

It is unclear whether SARS-CoV-2 can be transmitted through the aerosol route during GI endoscopic procedures. As more hospitals and endoscopy units are resuming prepandemic

Based on the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiological Research database, nationwide GI cancer age-adjusted mortality rates (AAMRs) per 100,000

Obesity is a known risk factor for colorectal cancer (CRC) in both men and women. A previously developed decision analytic was used to model the

This interesting opinion piece provides advice regarding a process for deciding whether to incorporate a new endoscopic technique into your practice. The authors suggest you

Malignant gastric outlet obstruction (GOO) requires prompt surgical or endoscopic decompression. Surgery is associated with significant morbidity and mortality. Fortunately, with the evolution of endoscopic

In this single-center study, 8 gastroenterology fellows and 20 practicing gastroenterologists answered a 10-question pretest regarding acute iatrogenic endoscopic perforation (AIEP) diagnosis and management. This

Randomized controlled trials of early versus late colonoscopy in acute lower GI bleeding suggest no or limited benefit from early colonoscopy, but some of these

Given a major increase (50%) in opioid prescriptions across the United States from 2000 to 2010, there is renewed interest in evaluating the effects of

With more than 6.1 million EGDs performed in the United States annually, establishing quality measures is imperative. Having well-defined quality measures can ensure consistency for

Artificial intelligence (AI) has been shown to increase adenoma detection rates (ADRs) by an average of about 10% in randomized controlled trials (RCTs). Meta-analyses of

This study identified 5 randomized controlled trials that addressed the value of a second right-sided colon examination in the forward view versus no second examination.

Endoscopists interested in reducing their carbon and plastic footprints will find this set of recommendations from the European Society of Gastrointestinal Endoscopy and the European

This is a retrospective study from 15 Western centers performing colorectal endoscopic submucosal dissection (ESD) in Europe and Australia.  A curative resection was defined as

Early-onset colorectal cancer (EOCRC), or CRC occurring before age 50, is associated with advanced tumor stage at diagnosis, distal colon location, and signet ring histology.

Recent guidelines have recommended peroral endoscopic myotomy (POEM) as first-line therapy for all subtypes of achalasia, given that POEM and laparoscopic Heller myotomy have comparable

A new GRADE guideline from the American College of Gastroenterology and Canadian Association of Gastroenterology includes recommendations for the periendoscopic management of anticoagulants and antiplatelets

We often hear that physician-identified large nonpedunculated colorectal polyps (LNPCPs) that warrant referral to an advanced endoscopist for endoscopic mucosal resection (EMR) or endoscopic submucosal

This report identified 46 studies that included 19,964 patients with ulcerative colitis (UC) in whom 73 cases of pouch cancer occurred and 3741 patients with

Nonvariceal upper gastrointestinal bleeding (NVUGIB) is potentially life-threatening and a common cause of hospitalization. Endoscopy is the procedure of choice for the evaluation and management

Patients with certain cancers expel volatile organic compounds (VOCs). VOCs are the basis of previous reports in which dogs were trained to identify patients with

“Tip-in” or “anchoring” endoscopic mucosal resection (A-EMR) involves submucosal injection followed by a small incision on the proximal side of the injection mound. The snare

Tip-in endoscopic mucosal resection (EMR) involves submucosal injection, followed by an incision on the proximal side of the injection mound using a snare tip with

The use of proton pump inhibitors (PPIs) has continually increased over the past 20 to 30 years. As a result, interest has grown in the

Cap-assisted EMR (EMR-C) involves submucosal injection followed by resection using a stiff Olympus cap (MH-597, Olympus Optical Co, Ltd, Tokyo, Japan) with an outer diameter

In a study performed in 10 Italian centers, 1137 colonoscopy patients completed validated questionnaires prior to colonoscopy and had symptoms from bowel preparation tracked. Overall,

High-sugar diets and hyperglycemia have been associated with colorectal cancer (CRC). In this study, investigators showed that ketogenic diets both prevented and treated CRC induced

Dyspepsia is a worldwide disease that interferes with quality of life. A 2010 systematic review investigated the prevalence of endoscopic findings in patients with dyspepsia;

The adenoma detection rate (ADR) is currently the recommended measure of the quality of mucosal inspection during colonoscopy. ADR does not include sessile serrated lesions

Thermal coagulation of the normal-appearing margin using snare tip soft coagulation (STSC) treatment after endoscopic mucosal resection (EMR) has been shown to reduce recurrence rates

At a single U.S. academic center with 20 endoscopists, including 13 academic and 7 voluntary, there were initial baseline measurements of first case on-time starts

Anal cancer is 10 times more common in HIV-positive men than cervical cancer is in women in the general population; however, women with HIV are

Discussions of colorectal endoscopic mucosal resection (EMR) versus endoscopic submucosal dissection (ESD) usually focus on en bloc resection and recurrence rates. Little is known about

The degree of dysplasia in patients with Barrett’s esophagus (BE) is key to determining the application of BE endoscopic therapy and assigning surveillance intervals. Multiple

Abdominal pain-related disorders of gut-brain interaction (AP-DGBI) affect a sizable portion of the population. Irritable bowel syndrome (IBS) is one of the most common forms

It is well known that mismatch repair-deficient colorectal cancer (CRC), also called microsatellite instability (MSI)-high CRC, fails to respond to traditional fluorouracil-based chemotherapy but has

Thermal treatment of the margin of piecemeal endoscopic mucosal resection (EMR) defects is now considered an effective treatment for reducing recurrences. Some practitioners have adopted

The motorized spiral enteroscope has been shown to be safe and effective for deep enteroscopy.  This study from a single center included 36 patients who

Most inoperable malignant biliary strictures are best treated with self-expanding metal stents (SEMS); however, a significant portion of patients develop stent occlusion from neoplastic or

Patients with stage III (node-positive) colorectal cancer (CRC) benefit from adjuvant chemotherapy. Patients with stage II (invading muscularis propia or deeper and node-negative) CRC typically

The thickness of submucosal tissue resection can be important for predicting whether the resection margin and submucosal assessment will be adequate when there is suspicion

For patients with complex benign esophageal strictures, including tight, long, or tortuous strictures, endoscopic dilation is usually performed at 2- to 4-week intervals. The success

This is a study of detection indicators in 13,067 fecal immunochemical test (FIT)-positive colonoscopies performed by 80 community gastroenterologists. The cutoff for FIT positivity was

This study utilized the Kaiser Permanente Northern California (KPNC) health care system to evaluate the actual impact of the COVID-19 pandemic on colorectal cancer (CRC).

This study looked at a large health care system’s first-time screening colonoscopies from the period October 2017 through December 2018, prior to the American Cancer

Gastric cancer is the third most common cause of cancer-related death in the world. Through the intestinal metaplasia pathway, Helicobacter pylori is a class 1 carcinogen and

Benign distal biliary strictures (BBS) are common sequelae of chronic pancreatitis. The usual treatment involves prolonged maximal-caliber stenting, using either serial exchange of multiple plastic

In parallel-arm randomized trials involving mostly primary screening and surveillance colonoscopy patients, computer-aided detection (CADe) has increased the adenoma detection rate (ADR) by about 10%.

ORISE (Boston Scientific, Marlborough, Mass, USA) is a viscous gel for submucosal injection. When ORISE is used for endoscopic mucosal resection (EMR) or endoscopic submucosal

Detection skills by gastroenterology fellows are difficult to quantitate. One way to measure detection is to have the fellow perform a complete colonoscopy and clear

A computer-assisted diagnosis (CADx) program is artificial intelligence (AI) software that predicts histology. In a prospective evaluation of the Fujifilm CADx program (CAD EYE, Fujifilm

Previous studies have indicated that cold snare polypectomy effectively removes colorectal lesions up to 15 mm in size but cuts more superficially than hot snare

Most studies of colonoscopy complications examine adverse event rates at a single time point. The Department of Veterans Affairs Cooperative Study #380 was one of

Motorized spiral enteroscopy (MSE) is innovative technology designed to facilitate advancement of the enteroscope across the small bowel. Preliminary studies have shown MSE to be

Widely accepted predictors of local recurrence after endoscopic resection of T1 cancers include rectal location, positive resection margin, poor differentiation (PD), lymphovascular invasion (LVI), high-grade

T2 colorectal cancers (CRCs) are almost invariably treated by surgical resection, but only 25% have lymph node metastases (LNM). An alternative approach in selected cases

Distal attachments that utilize fingers include the Endocuff Vision (Olympus America, Center Valley, Penn, USA) and AmplifEYE (Medivators Inc, Minneapolis, Minn, USA). An alternative approach

The hamartomatous polyposis syndromes include Peutz-Jeghers syndrome, juvenile polyposis syndrome, PTEN hamartoma tumor syndrome (Cowden’s and Bannayan-Riley-Ruvalcaba syndromes), and hereditary mixed polyposis syndrome. This document is a

Previous studies have found that a cold snare is more effective than cold forceps for polypectomy of polyps ≥4 mm in size, but data are

Cold snare polypectomy is now accepted as safer than hot resection of lesions ≤10 mm in size, though it is still widely believed that electrocautery

A free resection margin, often interpreted as >1 mm between cancer and the resection line, is an independent predictor of low risk for recurrent cancer

Randomized controlled trials (RCT) of emergency surgery versus colonic stent placement using self-expandable metal stents (SEMS) have mostly suggested limited or no benefits from SEMS.

The first requirement in detecting subtle colorectal lesions during colonoscopy is to know what they look like. In this study from Minneapolis, a poster with

Refractory gastroparesis (RG) negatively impacts the quality of life, and treatments to date have worked variably. Gastric peroral endoscopic myotomy (G-POEM), first performed in 2013,

The U.S. Multi-Society Task Force on Colorectal Cancer recommends minimally acceptable adenoma detection rates (ADRs) in primary screening colonoscopy of 30% in men and 20%

Artificial intelligence (AI) programs for computer-aided detection (CADe) of colorectal polyps have increased adenoma detection rates (ADR) by about 10% in parallel randomized trials and

Prophylactic clipping is generally considered effective for endoscopic mucosal resection (EMR) defects of lesions ≥20 mm removed with electrocautery and proximal to the splenic flexure. 

This systematic review and meta-analysis sought to quantify the differences in outcomes after endoscopic submucosal dissection (ESD) of rectal lesions at the dentate line versus

Pancreatic necrosis often results in main pancreatic duct injury and eventual discontinuity, or so-called disconnected pancreatic duct syndrome (DPDS), with recurrent symptoms from duct obstruction

Linked color imaging (LCI) emphasizes red color and is available on Fujinon endoscopes (Fujifilm Corp, Tokyo, Japan). Previous studies found LCI improved adenoma detection and

This report describes a 4-year prospective, observational assessment of fecal microbiota transplantation (FMT) performed in 681 health care facilities across 50 U.S. states and 7

This is a meta-analysis of 12 eligible randomized controlled trials with a total of 4165 patients that compared the effect of education using a smartphone

GERD, manifested by typical symptoms of heartburn as well as regurgitation and additional extraesophageal symptoms, such as chronic cough, sore throat, and globus sensation, affects

Guidelines have often recommended the continuation of clopidogrel for diagnostic colonoscopy but discontinuation for polypectomy, which is impractical because polypectomy rates are so high during

This study used the VA Cooperative Screening Colonoscopy Study, one of the pivotal trials that led to federal legislation directing the Centers for Medicare and

Population-based studies have found no decline in colectomy rates for benign colorectal polyps over the past 10 to 15 years, even though a recent study

This study evaluated 168,701 individuals with a positive fecal occult blood test (FOBT) result, of whom 80.5% underwent colonoscopy within 12 months. Compared with patients

Pancreatic ductal adenocarcinoma (PDAC) continues to have a dismal prognosis at the time of presentation. Survival is improved with diagnosis at an early stage, but

The increasing use of anticoagulant and antiplatelet agents has made the management of these medications during and around the time of endoscopy for GI bleeding

Irritable bowel syndrome (IBS) can be managed with a variety of treatments but commonly with diet and medications. This document from the American Gastroenterological Association

The adenoma detection rate (ADR) predicts the incidence of interval cancer after colonoscopy. Although ADR correlates in retrospective studies with other detection measures, it is

In 2017, the Centers for Medicare and Medicaid Services (CMS) instituted a small relative value unit (RVU) reduction in the professional fee payment for endoscopy

Cold snare resection is well established as comparably effective to and safer than hot snare resection for lesions ≤10 mm in size.  In a study

In a randomized tandem study of 230 patients, the adenoma miss rate (AMR) was lower at 15.5% when colonoscopy with artificial intelligence (AI) was performed

This is a post-hoc propensity score-matched analysis of 2498 colorectal lesions removed with needle-type or scissor-type knives for endoscopic submucosal dissection (ESD) in 11 Japanese

Patients with locally advanced rectal cancer who undergo neoadjuvant chemoradiation sometimes have remarkable responses to treatment. These may include evidence of no residual disease or

Green tea contains catechins, which have anticancer properties and reduce the incidence of polyps in mouse models with a mutation in the Adenomatous polyposis coli gene.  In

During the COVID-19 pandemic, the Veterans Health Administration (VHA) instituted a national policy converting screening colonoscopy to fecal immunochemical testing (FIT) to manage reduced access

Individuals diagnosed with head and neck squamous cell carcinoma (HNSCC) are known to have an increased risk of developing a second primary tumor in the

Proton pump inhibitors (PPIs) are prescribed for various indications, sometimes with clear evidence-based benefit and sometimes with little to no proven benefit. The purpose of

Recent studies have added complexity to our understanding of postpolypectomy surveillance risk, such as the risk of metachronous advanced neoplasia is higher with 6- to

A previous study of U.S. inpatients suggested that the frequency of splenic injury was about 1 in 6000.  The current study utilized 2012-2018 data from

Previous studies have indicated that the rectosigmoid colon location is an independent risk factor for cancer in large nonpedunculated colorectal polyps. Surgical procedures for cancer

A small subset of patients who undergo Barrett’s endoscopic therapy (BET) using radiofrequency ablation (RFA) will have evidence of poor mucosal healing (mucosal edema, ulcers,

Endoscopic submucosal dissection (ESD) is technically difficult and relies on appropriate countertraction and visibility to safely remove lesions of interest. Robot-assisted endoscopy has been under

According to 2014-2020 data from the GI Quality Improvement Consortium (GIQuIC) Registry, 2.81 million screening colonoscopies were performed by 814 endoscopists in patients aged 45

This was a case-control study of patients undergoing screening colonoscopy between 2013 and 2015. Patients completed a detailed diet and bowel habit questionnaire, and a

Endoscopic submucosal dissection (ESD) for T1 rectal cancer can leave positive margins, particularly for lesions invasive to the middle or deep thirds of the submucosa.

Many endoscopists utilize simethicone (SIM) in their bowel preparations for colonoscopy. This systematic review and meta-analysis identified 38 randomized controlled trials relevant to SIM impact

In the current study, a medical center in Thailand instituted a formal educational program focused on personal awareness of endoscope handling and manipulation, the correct

Clinical response after peroral endoscopic myotomy (POEM) is subjectively assessed using the Eckardt score (ES) or objectively tested using high-resolution manometry (HRM) or barium esophagram.

Direct oral anticoagulants (DOACs) are often stopped a couple of days before colonoscopy and resumed one or more days after the procedure, depending on thromboembolism

Colonoscopy for acute lower GI bleeding is usually performed after bowel purge. In a retrospective study with clinical diverticular bleeding, 266 patients received bowel preparation

The incidence of celiac disease has been increasing over time and is commonly encountered in GI practice. Although a gluten-free diet leads to pathologic disease

This study investigated outcomes in patients who underwent endoscopic submucosal dissection (ESD) for T1 colorectal cancer (CRC) and then had adverse histologic features that predict

In a randomized controlled trial (RCT) performed at 8 hospitals in 4 countries, patients with nonpedunculated polyps ranging in size from 4 to 9 mm

This study was a double-blind, randomized, placebo-controlled trial. It included patients with ≥3 episodes of C difficile infection (CDI) within 12 months, including the qualifying acute episode.

Barrett’s esophagus (BE) is a known precancerous lesion for esophageal dysplasia and adenocarcinoma (EAC); however, it is unclear who will progress to high-grade dysplasia (HGD)

The American College of Physicians (ACP) has issued a clinical guideline regarding acute left-sided diverticulitis. There are 3 recommendations, which were developed using the GRADE

This guideline from the American College of Physicians appears with a summary of the supporting literature review and has 3 recommendations: Colonoscopy should be performed

Transmission of multidrug-resistant organisms between patients undergoing ERCP prompted the U.S. Food and Drug Administration to issue guidance for endoscopy departments to adopt intensified reprocessing

Traditionally, nonampullary small-bowel adenomas ≥10 mm in diameter are resected utilizing cautery. Unfortunately, since the small bowel is thin-walled and highly vascular, adverse events are

Empiric esophageal dilation often is performed for patients presenting with dysphagia who have no evidence of an anatomic obstruction or lesion. However, there is little

Recent large randomized controlled trials have demonstrated that clip closure reduces the risk of delayed hemorrhage after endoscopic mucosal resection (EMR) using electrocautery if the

This was a retrospective analysis of bleeding after cold snare polypectomy (CSP) and hot snare polypectomy (HSP) for colorectal lesions with a diameter <10 mm.

Computer-aided detection (CADe), or artificial intelligence (AI), programs are now commercially available and have been shown to increase the adenoma detection rate. These AI programs

Randomized controlled trials (RCT) show that underwater EMR (UEMR) is more likely than conventional EMR (CEMR) to result in en bloc and R0 resection for

Informed consent is mandatory before an endoscopic procedure. Its purpose is to educate the patient about the procedure and review the associated risks, benefits, and

This study from 3 U.S. centers is the first to compare the second-generation Endocuff Vision (Olympus America, Center Valley, Penn, USA) to distal cap (Reveal;

Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) have emerged as important treatment techniques for patients with visible lesions in Barrett’s esophagus (BE). Whereas

Electrohydraulic lithotripsy (EHL) and laser lithotripsy are both well-established methods for the treatment of biliary and genitourinary stones. Several retrospective series have described successful pancreatoscopy-guided

Over the past decade, with advances in endoscopic resection (ER) techniques, there has been a trend toward removing early gastric cancer (EGC) with ER, especially

This study used the Utah Cancer Registry to examine cancer risk in patients with serrated polyposis syndrome (SPS) and their relatives as well as patients

Previous attempts to improve polyp detection during colonoscopy using extreme wide-angle or side-viewing optics have been unsuccessful, largely because of issues with diminished image resolution

This study looked at issues of technical success and acceptance of panendoscopy with a colon capsule in 451 generally healthy adults aged 50 to 75

In a prospective study, 2 experts independently assessed the surfaces of 400 large, laterally spreading colorectal lesions (median size, 35 mm) for predictors of submucosal

Including epinephrine in the submucosal injectate for endoscopic mucosal resection (EMR) varies among endoscopists – some endoscopists prefer epinephrine, whereas others do not. Of those

In a study from Iceland, investigators compared GI bleeding rates among 3217 patients receiving rivaroxaban, 2157 receiving apixaban, and 494 receiving dabigatran. Patients were excluded

The impact of colonoscopy on work productivity was assessed prospectively in 1137 employed patients in 10 Italian centers, utilizing a diary for 7 days after

We often tell our patients with colorectal cancer (CRC) or advanced adenomas that guidelines indicate their siblings are at increased risk of developing CRC or

Endoscopic therapy for Barrett’s esophagus (BE) usually involves resection of visible lesions by endoscopic mucosal resection followed by mucosal ablation using radio frequency ablation. Hybrid

One approach sometimes used in endoscopic mucosal resection (EMR) to improve complete resection is to use cautery to mark the normal tissue at the margins

This report from The Netherlands describes the results of a survey of 118 participants in an endoscopic submucosal dissection (ESD) training workshop using live porcine

Artificial intelligence (AI) that highlights lesions seen at endoscopy is called computer-aided detection (CADe) or detection software. Computer-aided quality (CAQ) programs assess the completeness of

Collagenous gastritis (CG) is an uncommon disorder characterized by subepithelial collagen deposition in the stomach. Symptoms vary depending on the phenotype (pediatric-onset vs adult-onset). Treatment

Anecdotally, many colonoscopists still use forceps to remove small and diminutive colorectal polyps that are more effectively and efficiently removed by snare polypectomy. In 2

Cold snare polypectomy is now considered the resection method of choice for colorectal lesions ≤10 mm in size. Dedicated snares with a wire diameter about

Previous randomized controlled trials (RCTs) have indicated that prophylactic clip closure is effective in preventing delayed hemorrhage after EMR of colonic lesions that are ≥20

The balloon expulsion test (BET) is a screening tool for rectal evacuation disorders. BET is often performed in conjunction with anorectal manometry. In this report,

Gluten exposure triggers an immune reaction in celiac disease that is associated with an increased risk of GI cancers. In this study, the effect of

Superficial esophageal squamous cell carcinoma (ESCC) involving the epithelium and lamina propria is treated with endoscopic resection (ER) due to negligible risk of lymph node

In a recommendation characterized as “weak recommendation; low-quality evidence,” the U.S. Multi-Society Task Force on Colorectal Cancer (MSTF) now recommends initiating screening for colorectal cancer

Patients with laterally spreading lesions and endoscopic evidence of T1 cancer (usually of morphologic change combined with NBI International Colorectal Endoscopic classification 3 or Kudo

In a study of fecal immunochemical test-positive patients in France, 1256 large polyps (LPs), defined as polyps ≥20 mm, were detected by 102 community gastroenterologists.

Peroral endoscopic myotomy (POEM) is an endoscopic procedure that exposes the contents of the esophagus to the sterile mediastinum during the myotomy. This allows microbial

Endoscopic resection (ER) of early gastric neoplasia is being performed with increasing frequency by endoscopists. Complete and accurate reporting of pathology is imperative to provide

Cholecystectomy before hospital dismissal is advised for most cases of acute biliary pancreatitis (ABP). Surgery is often delayed in the setting of pancreatic necrosis to

The Diverticular Inflammation and Complication Assessment (DICA) endoscopic scale is a scoring system that predicts diverticulitis and related surgery. Briefly, this scale takes into account

Four previous randomized controlled trials of flexible sigmoidoscopy (FS) have shown reductions in at least distal colorectal cancer (CRC) incidence and mortality after FS screening. 

Radiofrequency ablation (RFA) is widely utilized in the treatment of neoplastic Barrett’s esophagus (BE) after endoscopic resection of all visible lesions. Cryotherapy is another form

These evidence-based recommendations from the European Society of Gastrointestinal Endoscopy (ESGE) cover principles of tissue sampling and removal in the lower GI tract. Some points

Endocuff Vision (ECV; Olympus America, Center Valley, Pa) has produced adenoma detection rate (ADR) gains in randomized controlled trials, but it has not received widespread

The adenoma detection rate (ADR), first recommended by the U.S. Multi-Society Task Force on Colorectal Cancer in 2002, is a validated predictor of colorectal cancer

This article uses data from multiple sources to estimate gastrointestinal, liver, and pancreatic health care expenditures, ambulatory visits, and hospitalizations, as well as endoscopic procedural

As birth cohorts younger than age 50 become progressively younger, the relative increase in colorectal cancer (CRC) risk compared to past decades becomes progressively greater.

Patients are often concerned that chronic constipation will put them at risk for colorectal cancer (CRC), and previous data on this topic have been mixed.

Gastroparesis is a vexing problem and often has overlapping symptoms with functional dyspepsia. In this update from the American Gastroenterological Association, medically refractory gastroparesis is

Gastroesophageal reflux disease (GERD) is the most common reason for referral for upper endoscopy. This study sought to determine whether there is a relationship between

Many patients with walled-off pancreatic necrosis (WON) require debridement following minimally invasive drainage. This often entails serial procedures with cumulative expense and risk. These authors

Very large retrospective studies of withdrawal time and colonoscopy yield have indicated that interval cancer prevention levels out with a withdrawal time of 8 to

In a meta-analysis of 14 studies of colorectal endoscopic full-thickness resection (EFTR) involving 1936 patients, 76% of lesions were in the colon and the remainder

This report from the World Gastroenterology Organisation (WGO) reviews the potential health impact of climate change on GI disease, but it also calls on gastroenterology

Ampullary, periampullary, and duodenal adenomas commonly occur in familial adenomatous polyposis (FAP). Their detection and management are fraught with challenges related to balancing the risk

The American Society for Gastrointestinal Endoscopy recommends that gastroenterology fellows complete a minimum of 130 EGDs and 275 colonoscopies before assessing competency.  In a survey

Germline genetic testing for inherited colorectal cancer syndromes often is recommended in patients with ≥10 cumulative adenomas. However, the evidence to support this recommendation is

The accurate diagnosis and management of patients with Barrett’s esophagus (BE) are important for the early recognition and minimally invasive treatment of BE neoplasia. Despite

Artificial intelligence (AI) systems using convolutional neural networks have been developed to differentiate between esophageal cancer (EAC), high-grade dysplasia, and nondysplastic Barrett’s esophagus. However, until

In a trial of 199 patients aged 65 to 80 years, standard oral sulfate solution (OSS) was compared with 2-L polyethylene glycol with ascorbic acid

Older studies have suggested that the prevalence of cancer detected with average-risk screening colonoscopy is 0.5% to 1% or about 1 cancer per 100 to

In 2015, the U.S. Multi-Society Task Force (MSTF) on Colorectal Cancer, composed of members of the 3 luminal GI societies, recommended that patients with inadequate

Everyone performing EMR in the colorectum encounters flat or fibrotic polyp tissue that resists standard snaring.  In a multicenter European study, 70 nonlifting polyps with

A variety of techniques have been described for achieving deep biliary cannulation, a necessary prelude to most endoscopic retrograde cholangiographic (ERCP) procedures. The rate of

Bleeding after endoscopic submucosal dissection (ESD) is one of the most common adverse events, but the risk of post-ESD bleeding varies, depending on antiplatelet or

With the advent of screening average-risk persons beginning at age 45, many are wondering whether minimum acceptable adenoma detection rate (ADR) thresholds will need adjustment,

Endoscopic full-thickness resection (eFTR) can be used for lesions <30 mm in size, and when used for early colorectal cancer (CRC), it provides a histologic

Postendoscopic coagulation syndrome (PECS) is common after endoscopic submucosal dissection (ESD), and prior data have indicated that perioperative antibiotics reduced the syndrome.  In this Japanese

Artificial intelligence programs that detect lesions are called computer-aided detection (CADe) systems. Randomized controlled trials of CADe for colonoscopy have, thus far, mostly been performed

Among upper gastrointestinal (UGI) cancers, gastric and esophageal cancers rank third and sixth, respectively, as the most common cause of death due to cancer worldwide.

The incidence of esophageal adenocarcinoma (EAC) continues to increase and is still associated with a poor prognosis with a 5-year survival rate of 20%. The

Zenker’s diverticulum (ZD) can lead to dysphagia to both solids and liquids and can be treated endoscopically or surgically. This retrospective, single-center, observational study evaluated

Experienced colonoscopists have seen occasional patients date the onset of irritable bowel syndrome (IBS) to colonoscopy (and, occasionally, patients who date improvement of digestive symptoms

Patients with atrophic gastritis (AG) are at increased risk for gastric cancer; however, the diagnosis and surveillance of AG are not well-defined. Algorithms for the

The optimal technique for gastrostomy tube placement remains undefined. This retrospective study used the Nationwide Readmissions Database and the International Classification of Diseases Procedure Coding

Limited reports have suggested that endoscopic biliary sphincterotomy (ES) at the time of transpapillary biliary stent placement may reduce the risk of post-ERCP pancreatitis (PEP).

In a 2019-2020 academic year survey of all 1730 GI fellows in the U.S. regarding endoscopic mucosal resection (EMR) training and knowledge, the response rate

This study utilized a database of women and their prenatal care between 1959 and 1966, involving 18,751 live births and 14,507 mothers. Sixty-eight offspring developed

In a multicenter, multinational study, retrospectively obtained data for 379 patients showed 615 sessile serrated lesions ≥10 mm in size resected by cold snare polypectomy

Numerous studies have found that colonoscopies performed by nongastroenterologists are associated with lower rates of polyp detection and higher rates of interval cancer than colonoscopies

During endoscopy, the extent of Barrett’s esophagus (BE) is quantified by endoscopists using the widely accepted Prague C&M (circumferential and maximal lengths) criteria. Prague C&M

Spastic esophageal motility disorders (SEMDs) include a group of esophageal dysmotility conditions that are difficult to treat and often refractory to nonsurgical and/or endoscopic measures.

Anastomotic leak after low anterior resection is a dreaded complication. Patients with generalized peritonitis must undergo surgery, and treatment of localized walled-off leaks is not

This study examined the risk of colorectal cancer (CRC) associated with serrated polyp subtypes in patients undergoing their first colonoscopy between 2006 and 2016. There

This guideline from the British Society of Gastroenterology and the European Society of Gastrointestinal Endoscopy relies on the traditional division of procedures into low risk

In this study from Sweden, 58,657 persons aged 50 years and older prescribed melatonin were matched with 175,971 nonusers of melatonin. The adjusted hazard ratio

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer mortality since most cancers are advanced at diagnosis. Early identification of these cancers is

Standardized quality metrics evaluating the performance of a high-quality examination in patients with Barrett’s esophagus are lacking. The neoplasia detection rate (NDR), defined as the

In a single-center randomized controlled trial from Germany, 148 nonpedunculated lesions 20 to 40 mm in size were included in a per-protocol analysis and randomized

Interval cancers are thought to result primarily from missed lesions, with a smaller component in the 10% to 30% range arising from incomplete polyp resection.

Intense ongoing investigation has suggested a number of risk factors for early-onset colorectal cancer (EOCRC), defined as CRC in persons younger than aged 50 years

Underwater endoscopic mucosal resection (UEMR) has been increasingly utilized in the resection of colonic and duodenal mucosal lesions. Its use for resection of nonpolypoid superficial

Polyp size measurements by endoscopists during colonoscopy are notoriously inaccurate, with both over-measurements and under-measurements. Computerized assessments of polyp size are promising for more accurate

Those at high risk or with a prior history of esophageal squamous cell cancer (SCC) are recommended to undergo screening or surveillance using dye-based chromoendoscopy.

Tip-in EMR is a method of anchoring the snare tip in the submucosa before snare resection. First, a mound of submucosal injection is created. Then,

Double right-sided colon examination has been advocated as a way to reduce interval cancers, which are more common in the proximal colon. Mucosal exposure devices,

Previous studies have been inconclusive as to whether endoscopic screening contributes to patients leading a healthier or unhealthier lifestyle. For example, patients with normal examinations

The fecal immunochemical test (FIT) is widely chosen by organized colorectal cancer (CRC) screening programs as the screening test of choice. FIT detects about 80%

Patients with high-grade dysplasia and/or early cancer in Barrett’s esophagus (BE) are treated with endoscopic therapy (BET), with the goal of complete eradication of all

Several recent studies have collectively reported that surgery rates for benign colorectal polyps in the U.S. have continued to increase even though surgery results in

Many investigators are trying to understand the increasing risk of colorectal cancer (CRC) developing before age 50, or so-called early-onset CRC.  The Nurses’ Health Study

This study utilized the Nurses’ Health Study II data to evaluate a sulfur microbial diet (high intake of processed meats and low intake of vegetables

Although ulcerative colitis and Crohn’s colitis are associated with an increased risk of colorectal cancer (CRC), chronic inflammation associated with microscopic colitis (MC) has not

Establishing a firm diagnosis for indeterminate biliary strictures is often challenging. The current standard of practice is fluoroscopic and cholangioscopic characterization with brush and biopsy

The U.S. Multi-Society Task Force on Colorectal Cancer recommends individualizing the decision to stop surveillance colonoscopy in patients aged 75 years and older.  This is

When a patient is compliant with bowel preparation instructions, but the preparation is inadequate, there are little data from controlled trials to guide the bowel

Five randomized controlled trials (4 from China and 1 from Europe and the U.S.) have demonstrated that artificial intelligence (AI) increases the adenoma detection rate

Data vary regarding whether hypergastrinemia and proton pump inhibitor (PPI) use increase adenoma progression and risk of colorectal cancer (CRC).  The current study from the

Peroral endoscopic myotomy (POEM), an endoscopic modality for managing major esophageal motility disorders, has gained popularity in the last decade. Multiple controlled studies and systematic

A practice update from the American Gastroenterological Association used expert review and focus on methodologies to develop best practice recommendations for the management of endoscopic

A combination of fluoroquinolone (ciprofloxacin, levofloxacin) and metronidazole is the most commonly used antibiotic treatment for outpatient diverticulitis. However, the U.S. Food and Drug Administration

Currently recommended minimum thresholds for adenoma detection rates (ADRs), defined as the fraction of patients undergoing first-time screening colonoscopy who have one or more conventional

The phenotypes of eosinophilic esophagitis (EoE) range from mild inflammation to severe fibrostenotic disease. Although current therapies (diet, proton pump inhibitors, and steroids) have shown

On average, colonoscope insertion is considered more difficult in women than men, and most colonoscopists meet patients, including women, who request an attempt at unsedated

In this study from a French hospital, 296 patients with familial adenomatous polyposis (FAP) underwent either proctocolectomy with ileoanal anastomosis (IAA; 31.1%) or abdominal colectomy

This Chinese study examined 367 patients in a retrospective cohort and 238 in a prospective group for the amount of fecal Fusobacterium nucleatum, quantitated by

Diagnosis of celiac disease has increased significantly over the past decade. The risk of cancer in this patient population is thought to be increased, although

In a meta-analysis involving 36 studies and 2788 patients with serrated polyposis syndrome (SPS), the overall risk of colorectal cancer (CRC) was 19.9%. However, most

Many U.S. cancer registries extend back to only a few years before cancer incidence in younger people began to rise, but the Connecticut Tumor Registry

In 2020, the U.S. Food and Drug Administration and other similar bodies recalled all ranitidine products, secondary to a possible increased association with several types

These are highlights of the European Society of Gastrointestinal Endoscopy’s new guideline on the diagnosis and management of acute lower GI bleeding: In cases of

Peroral endoscopic myotomy (POEM) is a widely accepted, effective endoscopic procedure for the management of achalasia. Although POEM is considered a relatively safe procedure, studies

Cold EMR is increasingly popular because of its low risk of complications. However, there do seem to be more recurrences after cold EMR.  In a

Traditionally, room lights are turned down quite low during endoscopy. In a single-center retrospective study, 498 colonoscopies were performed by 9 gastroenterologists in low light

Fifteen years ago, tools to close acute perforations during colonoscopy became available, beginning with hemostatic clips, followed by over-the-scope clips and suturing.  To examine the

The U.S. Preventive Services Task Force (USPSTF) recommendations are key for screening because they influence the policies of the Centers for Medicare and Medicaid Services

Before endoscopic resection, large nonpedunculated colorectal lesions should be thoroughly inspected for evidence of submucosal invasive cancer (SMIC). The features to look for are disruption

This report from the U.S. evaluated 144 patients undergoing surgical resection for benign colorectal polyps. There were 118 referred patients without an attempt at endoscopic

Eosinophilic esophagitis (EoE), a chronic inflammatory disorder, can be treated with steroids, proton pump inhibitors, and dietary modifications. There have been advances in the formulations

The ability of video capsule endoscopy (VCE) to detect small-bowel (SB) pathology is dependent on adequate visibility and motility. This single-center, prospective, randomized, controlled trial

High-risk T1 colorectal cancer means there are adverse histologic features associated with an increased risk of lymph node metastases (LNM). The features are typically deep

Laterally spreading lesions on the ileocecal valve (ICV) have traditionally been among the most challenging to resect endoscopically, and some centers refer them for surgical

Gastroesophageal reflux disease (GERD), a relatively common condition impacting up to 40% of the adult population, can be treated with proton pump inhibitors (PPIs), laparoscopic

In this Japanese study from 5 institutions, 1147 pedunculated (stalk length of ≥5 mm) colorectal polyps were evaluated for predictors of immediate bleeding after being

Biliary obstruction with associated cholangitis usually is managed with the use of endoscopic retrograde cholangiopancreatography (ERCP) for stone extraction or stent decompression of the bile

Currently, an upper GI endoscopy with biopsies of the columnar-lined distal esophagus is necessary to diagnose Barrett’s esophagus (BE). Easier, noninvasive, nonendoscopy-based testing techniques have

Universal screening of colorectal cancers (CRCs) is recommended to increase the diagnosis of Lynch syndrome. Tumor screening can be done by microsatellite instability (MSI) testing,

Randomized controlled trials comparing the use of colonoscopy to the fecal immunochemical test (FIT) for colorectal cancer (CRC) screening are underway.   A case-control study from

Differentiating pancreatic mucinous from nonmucinous cysts can be challenging, and the pancreatic cyst fluid (PCF) carcinoembryonic antigen (CEA) level has suboptimal accuracy. Adjunct tests, such

The “other” cancers in Lynch syndrome include small-bowel, pancreatobiliary, urinary tract, and brain cancers, as well as sebaceous neoplasms. Routine screening for many of these

Compression of the distal bile duct within a fibrotic pancreas is one complication of chronic pancreatitis (CP), which can lead to chronic cholestasis, cholangitis, and

Current guidelines recommend universal screening of patients with newly diagnosed colorectal cancer (CRC) for tumor features of Lynch syndrome. This is usually done by immunohistocompatibility

We often hear about the idea of “leaky gut,” which refers to intestinal permeability resulting from medications or certain diets, and that this condition may

In a systematic review and meta-analysis of 280,370 screening colonoscopies in the literature, the pooled prevalence of sessile serrated lesion (SSL) detection was 2.5%. The

When patients have T1 colorectal cancer (CRC) resected, histologic features, such as deep submucosal invasion, poor differentiation, lymphovascular invasion, and high-grade tumor budding, are used

Referring physicians sometimes tattoo large nonpedunculated lesions before referral, and resectionists sometimes tattoo the resection site for easy identification of the scar later. Neither practice

Lynch syndrome is associated with increased cancer risk, particularly in the colorectum, as a result of germline mutations in any of 4 mismatch repair genes

The functional luminal imaging probe (FLIP) measures the distensibility index (DI) at the gastroesophageal junction (GEJ). This is a measure of GEJ compliance, which has

Cold EMR is becoming increasingly popular for large nonpedunculated colorectal lesions, particularly sessile lesions and adenomas without major 1s or pseudodepressed components. These researchers performed

A previous randomized controlled trial showed that thermal ablation of a normal-appearing EMR margin after complete polyp resection reduced the recurrence rate from 21% to

In an Italian study using a fecal immunochemical test (FIT)-positivity cutoff of 20 µg Hb/g feces, 88,013 FIT-positive patients (79%) underwent colonoscopy, and 23,410 (21%)

Severe acute cholecystitis (AC) often is palliated with percutaneous or endoscopic drainage 6 to 12 weeks prior to preplanned interval cholecystectomy. Many patients with severe

Laparoscopic antireflux surgery (ARS) is an effective treatment for patients with well-documented gastroesophageal reflux disease (GERD). In this retrospective cohort study, investigators used national databases

In clinical practice, colonoscopists sometimes think that patients with large nonpedunculated colorectal lesions should be referred to surgery after one or two attempts at resection

In a comparison of colonoscopy adherence after positive fecal immunochemical testing (FIT) in 2017 without patient navigation (PN) versus 2018 with navigation, overall completion of

More than 200,000 bariatric surgeries took place in 2018. Of these, 95% were either a sleeve gastrectomy or Roux-En-Y gastric bypass. Although the 90-day mortality

In a nationwide Swedish registry study, 24,786 colorectal cancer (CRC) cases and 74,358 randomly matched controls for birth year and sex were evaluated to determine

The UK revised its postpolypectomy surveillance guidelines to reduce the use of surveillance colonoscopy. According to the guidelines, patients considered to be high risk for

Persistent dysphagia (ie, symptoms for more than 3 months) after fundoplication surgery is reported in up to 25% of patients. After anatomical causes of dysphagia

Colonic diverticular bleeding (CDB) often stops spontaneously, and a meticulous colonoscopic search of the colon for the bleeding diverticulum is often unsuccessful. The “step-clipping” method

An individual patient data meta-analysis, which was performed for this study, utilizes the individual data from separate studies rather than summary data. However, this study

The optimal treatment for cholangiocarcinoma (CCA) or ampullary carcinoma (AC) is surgery. When deemed unresectable and not amenable to neoadjuvant therapy followed by liver transplantation,

This retrospective cohort study evaluated postpolypectomy bleeding and thromboembolism risks with warfarin, apixaban, dabigatran, and rivaroxaban use in Hong Kong public hospitals between January 2012

Clinicians everywhere struggle with colonoscopy bowel preparation in inpatients. In a randomized trial performed in 4 cities, 300 patients (180 mobile and 120 bedridden) received

Image-enhanced endoscopy is aimed at improving the detection of neoplastic lesions in the luminal GI tract during standard white-light endoscopy (WLE). Linked color imaging (LCI)

The potential for interpatient transmission of infections by contaminated duodenoscopes is a significant concern in the practice of ERCP. Pending further understanding and development of

When the adenoma detection rate (ADR) was originally proposed as a quality measure in 2002, the recommendation did not constrain its indication to screening colonoscopies

There are limited data on success rates of endoscopic submucosal dissection (ESD) in North America. In this study, 10 centers in the United States and

In this study, a virtual reality program playing nature and animal scenes was tested in 27 patients who had previously undergone moderate sedation for colonoscopy

Patients with functional dyspepsia (FD) and gastroparesis are commonly seen, diagnosed, and treated in gastroenterology clinics. Though we think of these diseases as two separate

Buried Barrett’s esophagus (BE) mucosa, or subsquamous intestinal metaplasia, is defined as intestinal metaplasia that is present under a lining of endoscopically intact squamous epithelium.

Recent analyses suggest that colonoscopy with the original Endocuff or newer Endocuff Vision (EV) is superior to standard colonoscopy but that Endocuff has a greater

Colonic endoscopic submucosal dissection (ESD) is generally considered more challenging than esophageal, stomach, or rectal ESD.  The authors have previously described a double-clip traction (DCT)

In a retrospective analysis of all multitarget stool DNA (mt-sDNA) tests ordered at a single center over one year by 62 primary care providers (50

Postpolypectomy surveillance recommendations are based on observational studies, often using advanced adenomas at follow-up as their primary outcome.  A new meta-analysis focused on the risk

In a nationwide biennial fecal immunochemical test (FIT) screening program in Taiwan, more than 5.4 million individuals were invited to undergo screening between 2004 and

Although esophageal adenocarcinoma (EAC) is the most common type of esophageal cancer in the Western world, esophageal squamous cell carcinoma (ESCC) is the dominant type

There has been significant media attention on the risks of proton pump inhibitors (PPIs) noted in observational studies, including associated risks of pneumonia, Clostridium difficile,

The optical features of sessile serrated lesions (SSLs) identified in narrow-band imaging are a cloud-like surface, indistinct borders, irregular shape, and dark spots. In a

The original Endocuff (EC) had two rows of fingers, whereas the currently marketed Endocuff Vision (ECV) has a single row of longer fingers. Although EC

Multiple guidelines recommend performing cholecystectomy (CCy) before hospital dismissal for patients with mild gallstone pancreatitis that is not complicated by infection or necrosis. In this

Colorectal cancer screening occurs broadly in two settings, termed “organized” and “opportunistic.” Organized programs are typically run by nations or health care systems and usually

In a prospective randomized trial including 320 average-risk screenees, polyps ≥6 mm were found more often with colon capsule endoscopy than with CT colonography (CTC;

Artificial intelligence (AI) studies for detecting and differentiating gastrointestinal lesions are on the rise. Various groups have developed a multitude of machine-learning algorithms to accurately

Ranitidine is a widely used H2-receptor antagonist used to treat reflux and peptic ulcer disease. Recently, the U.S. Food and Drug Association (FDA) discontinued sales

In a survey of primarily UK endoscopists (72% of all respondents) that included endoscopists from 45 countries and had an overall 20.2% response rate, the

In this study, researchers evaluated the Nurses’ Health Study (NHS) and Health Professional Follow-up Study (HPFS) databases to examine the association of diverticulitis with bowel

In a meta-analysis of 71 studies involving 5167 endoscopically treated T1 colorectal cancers (CRCs), the cumulative recurrence rate was 3.3%, the local recurrence rate was

There is now widespread recognition that there are increasing rates of colorectal cancer in persons under age 50 (early-onset colorectal cancer), that most of the

In a study from Japan, T1 colorectal cancers and adenomas were classified as “depressed,” “flat,” or “protruded” subtypes. Depressed lesions constituted only 1.2% of all

Laterally spreading lesions (LSLs) of the duodenum are increasingly being diagnosed and treated endoscopically. Although endoscopic resection of the thin and vascular duodenal wall is

In patients undergoing Barrett’s endoscopic therapy (BET), complete eradication of intestinal metaplasia (CE-IM) is the final goal. However, studies have reported recurrence of IM, specifically

Clip closure of endoscopic mucosal resection (EMR) defects ≥20 mm located proximal to the splenic flexure and removed by electrocautery is associated with a reduction

In various series, 2% to 7% of patients with colorectal cancer (CRC) have either synchronous or metachronous second cancer. Second CRCs have generally been considered