Lynch syndrome is caused by germline mutations in MLH1, MSH2, MSH6, or PMS2 genes, but the most commonly affected genes are MLH1 and MSH2. Increasingly, surveillance recommendations are on a gene-specific basis, with
PMS2
PMS2
No Metachronous Cancers Observed in MSH6 and PMS2 Carriers
No Metachronous Cancers Observed in MSH6 and PMS2 Carriers
Modeling Suggests Later Starting Age and 3-Year Intervals for Colonoscopy in MSH6 and PMS2
Modeling Suggests Later Starting Age and 3-Year Intervals for Colonoscopy in MSH6 and PMS2
Lynch syndrome is associated with increased cancer risk, particularly in the colorectum, as a result of germline mutations in any of 4 mismatch repair genes
