Sarcopenia (Loss of Skeletal Muscle Mass) Associated With Metachronous Adenomas

Sarcopenia (Loss of Skeletal Muscle Mass) Associated With Metachronous Adenomas

Douglas K. Rex, MD, FASGE, reviewing Yoo KM, et al. J Gastroenterol Hepatology 2020 Apr 29.

Sarcopenia is a progressive loss of skeletal muscle mass in relation to aging. Sarcopenia is associated with metabolic syndrome, diabetes, and nonalcoholic steatohepatitis and has been associated with a higher prevalence of adenomas at screening colonoscopy.

In a study of 14,701 Korean patients undergoing surveillance colonoscopy, and after adjustment for age, sex, smoking status, alcohol consumption, colorectal cancer family history, exercise, baseline adenoma risk, and metabolic syndrome, decreasing quartiles of skeletal muscle index were associated with overall adenomas (P<.001) and advanced adenoma (P=.049).

Douglas K. Rex, MD, FASGE

COMMENT

This effect, while interesting, is currently difficult to utilize, as skeletal muscle mass index is typically not measured in clinical practice. The authors consider that this effect is likely mediated through insulin resistance.

Note to readers: At the time we reviewed this paper, its publisher noted that it was not in final form and that subsequent changes might be made.

CITATION(S)

Yoo KM, Yang HJ, Park SK, et al. Skeletal muscle mass and risk of advanced adenoma in surveillance colonoscopy. J Gastroenterol Hepatol 2020 Apr 29. (Epub ahead of print) (https://doi.org/10.1111/jgh.15082)

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