Risk of Ileoanal Pouch Cancer Is Greater in Familial Adenomatous Polyposis Than in Ulcerative Colitis
Douglas K. Rex, MD, MASGE, reviewing Sriranganathan D, et al. Dig Liver Dis 2022 Jul 8.
This report identified 46 studies that included 19,964 patients with ulcerative colitis (UC) in whom 73 cases of pouch cancer occurred and 3741 patients with familial adenomatous polyposis (FAP) in whom 68 cases of pouch cancer developed. The pooled incidence was 0.3% in UC and 1% in FAP. In UC, 59% of cancers were in the pouch body versus 24% in the anal transition zone.
Note to readers: At the time we reviewed this paper, its publisher noted that it was not in final form and that subsequent changes might be made.
Sriranganathan D, Vinci D, Pellino G, Segal JP. Ileoanal pouch cancers in ulcerative colitis and familial adenomatous polyposis: a systematic review and meta-analysis. Dig Liver Dis 2022 Jul 8. (Epub ahead of print) (https://doi.org/10.1016/j.dld.2022.06.013)