No Increase in Adenomas in Microscopic Colitis
Douglas K. Rex, MD, MASGE, reviewing Kamboj AK, et al. Clin Gastroenterol Hepatol 2021 May 28.
Although ulcerative colitis and Crohn’s colitis are associated with an increased risk of colorectal cancer (CRC), chronic inflammation associated with microscopic colitis (MC) has not been associated with increased CRC risk.
In a multicenter study of 376 patients with MC and 752 controls with chronic diarrhea but no MC, the risk of adenomas at baseline examination was lower in MC. At follow-up, there was no association of MC with adenomas or advanced adenomas.
COMMENTThe authors suggest that the lower risk of adenomas at baseline examination in patients with MC could be from nonsteroidal use, which is associated with MC as well as lower adenoma prevalence. These data support the notion that patients with MC do not need more intense screening or surveillance for CRC beyond that appropriate for average-risk persons.
Note to readers: At the time we reviewed this paper, its publisher noted that it was not in final form and that subsequent changes might be made.
CITATION(S)
Kamboj AK, Zylberberg HM, Lane CM, et al. Microscopic colitis and risk of colon adenomas: a multicenter retrospective cohort study. Clin Gastroenterol Hepatol 2021 May 28. (Epub ahead of print) (https://doi.org/10.1016/j.cgh.2021.05.050)
