Microbiome Predicts Metachronous Colorectal Adenomas
Douglas K. Rex, MD, MASGE, reviewing Xue JH, et al. J Gastroenterol Hepatol 2021 Jun 13.
This Chinese study examined 367 patients in a retrospective cohort and 238 in a prospective group for the amount of fecal Fusobacterium nucleatum, quantitated by polymerase chain reaction. In the retrospective cohort, a high abundance of fecal F nucleatum was associated with an odds ratio of 6.38 for metachronous adenomas compared to a low abundance. This risk was substantially higher than with factors such as advanced adenoma and 3 or more adenomas at baseline, and neither of these showed an actual statistically significant difference. In the prospective cohort, the sensitivity of a high abundance of F nucleatum in the feces was 73% for adenomas, and the specificity was 65%.
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Xue JH, Xie YH, Zou TH, et al. Fecal Fusobacterium nucleatum as a predictor for metachronous colorectal adenoma after endoscopic polypectomy. J Gastroenterol Hepatol 2021 Jun 13. (Epub ahead of print) (https://doi.org/10.1111/jgh.15559)