Meta-analysis Associates Helicobacter pylori Infection With Colorectal Neoplasia
Douglas K. Rex, MD, FASGE, reviewing Choi DS, et al. Clin Transl Gastroenterol 2020 Feb.
Helicobacter pylori (H. pylori) infection has been previously associated with colorectal neoplasia, presumably via mechanisms of hypergastrinemia or intestinal dysbiosis.
In an up-to-date meta-analysis involving 48 studies and 171,045 patients, the odds ratios (ORs) for adenoma, advanced adenoma, and colorectal cancer with H. pylori infection were all increased at 1.49, 1.50, and 1.44, respectively. After adjustment for publication bias in the adenoma estimate, the risk remained increased with an OR of 1.39.
COMMENT
Many of the studies in the meta-analysis were small and with large effect sizes, and some were low quality. Nevertheless, the available evidence continues to indicate the real possibility that H. pylori infection is associated with an increased risk of colorectal neoplasia.
Note to readers: At the time we reviewed this paper, its publisher noted that it was not in final form and that subsequent changes might be made.
Douglas K. Rex, MD, FASGE
CITATION(S)
Choi DS, Seo SI, Shin WG, Park CH. Risk for colorectal neoplasia in patients with Helicobacter pylori infection: a systematic review and meta-analysis. Clin Transl Gastroenterol 2020;11:e00127. (https://doi.org/10.14309/ctg.0000000000000127)
