Early-Onset Colon Cancers Have More Synchronous Advanced Adenomas
Douglas K. Rex, MD, MASGE, reviewing Emiloju OE, et al. JAMA Netw Open 2023 Jul 3.
In a cross-sectional retrospective study at a single U.S. health care system, colonoscopic findings of 150 randomly selected patients with early-onset colorectal cancer (CRC) were compared with those of 150 patients with average-onset CRC, matched based on sex and colonoscopic indication. The median age of the patients with early-onset CRC was 43 years, and for patients with average-onset CRC, it was 67 years.
Among patients with rectal cancer, the prevalence of synchronous advanced adenomas was the same in the two groups (15% and 19%). However, among patients with colon cancer, synchronous advanced adenomas were more common in the early-onset group (41% vs 15%; P<.001).
COMMENTBased on age alone, this result is completely unexpected. It will be interesting to see whether it holds up to prospective testing. We should keep it in mind when clearing the colons of patients with early-onset CRC.
Note to readers: At the time we reviewed this paper, its publisher noted that it was not in final form and that subsequent changes might be made.
CITATION(S)
Emiloju OE, Saberzadeh-Ardestani B, Sinicrope FA. Synchronous neoplasia rates at colonoscopic diagnosis of early-onset vs average-onset colorectal cancer. JAMA Netw Open 2023;6:e2324038. (https://doi.org/10.1001/jamanetworkopen.2023.24038)
Ähnliche Beiträge
WASP classification
Recently sessile serrated lesions (SSLs) have been recognized as another
BEITRAG LESEN