This study utilized data from two cohorts of the Nurses‘ Health Study involving nearly 159,000 women and 3.5 million person-years of follow-up. The investigators discovered
colorectal cancer
colorectal cancer
Being Breastfed Associated With Increased Risk of Colorectal Cancer
Most Patients Who Have Not Had Colorectal Cancer Screening Have Not Been Offered Screening
Previous studies have shown that most patients who had not undergone colorectal cancer (CRC) screening reportedly had not been offered screening by their primary care
Cancers Detected in Second-Round Fecal Immunochemical Test Screening Still Early Stage
The value of colorectal cancer (CRC) screening lies in CRC prevention through polyp detection and prevention of CRC mortality by early-stage CRC detection. Compared with
Delay in Colonoscopy After Positive FIT May Be Lethal, Particularly in 40- to 49-Year-Olds
These data are from a population-based Chinese screening program involving 595,180 persons aged 40 to 74 years with 16 years of follow-up. There were 42,353
Early-Onset Colon Cancers Have More Synchronous Advanced Adenomas
In a cross-sectional retrospective study at a single U.S. health care system, colonoscopic findings of 150 randomly selected patients with early-onset colorectal cancer (CRC) were
Monoallelic Variants in Recessive CRC Genes Not Associated With Increased CRC Risk
Increasingly, we are consulted on or asked to perform colonoscopies on patients who previously underwent multigene panel testing for oncogenes associated with colorectal cancer (CRC).
To Optimally Prevent Colorectal Cancer, We Need to Detect Both Adenomas and Serrated Lesions
Recent studies have found that significant fractions of colonoscopists possess adequate detection of conventional adenomas, as measured by adenoma detection rate (ADR), but low detection
About Half of Cancers in Serrated Polyposis Syndrome Arise Through the Adenoma-Carcinoma Sequence
The serrated pathway of colorectal cancer (CRC) is considered to account for about 20% of all CRCs. Patients with serrated polyposis syndrome (SPS) have higher
Declines in Colorectal Cancer Incidence in Older Persons Are Slowing
This study used SEER (Surveillance, Epidemiology, and End Results) data to update colorectal cancer (CRC) incidence and mortality trends from 1992 to 2019. The well-known
In U.S. Veterans, Advanced Adenomas, Not Nonadvanced Adenomas, Before Age 50 Associated With Higher CRC Risk
Adenomas are commonly diagnosed in patients younger than age 50 undergoing colonoscopy. Adenomas in young people often initiate surveillance at shorter than the recommended intervals,
Colonoscopy Quality Appears To Be Good in U.S. Veterans Administration Hospitals
In a study of 29,877 patients with colorectal cancer (CRC) in the U.S. Veterans Affairs (VA) health care system, the rate of postcolonoscopy colorectal cancer
A New Treatment for Endoscopic Palliation of Colorectal Cancer
Patients with colorectal cancer (CRC) metastatic to the liver or lung often do not undergo surgical resection of their primary tumor. However, the primary tumor
Colonoscopy Screening at Intervals Longer Than 10 Years Is Feasible
Case-control studies and cohort studies have found that colonoscopy prevents colorectal cancer (CRC) for 15 to 20 years or more. However, only a few small
The Strongest Predictor of Colonoscopy Completion After a Positive Stool Test Is a Multitarget Stool DNA Test
It is well known that the rates of follow-up colonoscopy after a positive fecal screening test are suboptimal, and delays in colonoscopy versus prompt colonoscopy
Does Appendectomy Increase Risk of Colorectal Cancer?
This systematic review and meta-analysis identified 22 studies from 3 continents that addressed the risk of colorectal cancer (CRC) after appendectomy in the general population.
FIT-Fecal DNA Test Had High Positive Predictive Value in Second-Round Screening
This study examined the positive predictive value (PPV) of a second round of screening with a fecal immunochemical test (FIT)-fecal DNA test (Cologuard, Exact Sciences).
Colorectal Cancer Screening Rates Increased During the COVID Pandemic, but With Stool-based Tests, Not Colonoscopy
This report is from the National Health Interview Survey, an annual survey of U.S. households covering a wide range of health topics. Response rates were
Prediagnosis Obesity Eliminates Survival Advantage Associated With Aspirin Use in Stage IV Colorectal Cancer
This study divided 656 participants with stage IV colorectal cancer (CRC) into groups according to their prediagnosis body mass index (BMI): normal (38.3%), overweight (36.3%),
Review Indicates Colorectal Cancer Screening Guidelines Have Inadequate Reporting and Discussion of Screening Harms
Cancer screening can lead to patient-level harms from screening tests, diagnostic follow-up, and cancer treatment. This review examined U.S. screening guidelines on breast, cervical, colorectal,
First Randomized Controlled Trial Comparing Colonoscopy With No Screening Finds Less Benefit Than Expected for Colonoscopy
In the first report of incidence and mortality results from a randomized controlled trial (RCT) comparing colonoscopy with no screening, 84,585 previously unscreened persons aged
Dutch Describe Impact of Their National Biennial Fecal Immunochemical Test Screening Program
In 2014, the Netherlands instituted a national program of every-other-year fecal immunochemical test (FIT) screening for colorectal cancer (CRC). Since the start of screening, within
Risk-Stratified CRC Screening Using Fecal Immunochemical Test and Stool DNA
This is a post hoc analysis of a risk-stratification screening strategy based on the Asia-Pacific Colorectal Screening (APCS) scoring system. This score ranks patients as
Substantial Risk of Advanced Adenomas but No Colorectal Cancer in a Cohort of Patients With CDH1 Mutations
CDH1 mutations are associated with a very high risk of gastric cancer, early age of onset of gastric cancer, and a high risk of breast cancer
Global Trends in Colorectal Cancer
Data on colorectal cancer (CRC) incidence and deaths were extracted from the GLOBOCAN database for 2020, and projections were made for 2040. Some of the
Interval Cancers Are More Deadly Than Screen-Detected Cancers but Are Not Different in Molecular Features
Previous studies have found that interval or postcolonoscopy cancers have molecular profiles that differ somewhat from those of cancers detected at a baseline colonoscopy, including
Breath Test for Colon Cancer Shows Promise
Patients with certain cancers expel volatile organic compounds (VOCs). VOCs are the basis of previous reports in which dogs were trained to identify patients with
12 of 12 Patients With Mismatch Repair-Deficient, Locally Advanced Rectal Cancer Had Complete Response to Dostarlimab Alone
It is well known that mismatch repair-deficient colorectal cancer (CRC), also called microsatellite instability (MSI)-high CRC, fails to respond to traditional fluorouracil-based chemotherapy but has
Liquid Biopsy After Resection of Stage II Colon Cancer Reduced the Need for Adjuvant Chemotherapy
Patients with stage III (node-positive) colorectal cancer (CRC) benefit from adjuvant chemotherapy. Patients with stage II (invading muscularis propia or deeper and node-negative) CRC typically
Actual Impact of COVID-19 on CRC (8.7% Reduction) and Advanced Adenoma (26.9% Reduction) Diagnoses in a U.S. Health Care System
This study utilized the Kaiser Permanente Northern California (KPNC) health care system to evaluate the actual impact of the COVID-19 pandemic on colorectal cancer (CRC).
Endoscopic Submucosal Dissection for Early Colorectal Cancer and High-Risk Surgery: Okay to Not Operate
This study investigated outcomes in patients who underwent endoscopic submucosal dissection (ESD) for T1 colorectal cancer (CRC) and then had adverse histologic features that predict
Cancer Risk in Serrated Polyposis Syndrome and Sporadic Sessile Serrated Lesion Patients and Their Relatives
This study used the Utah Cancer Registry to examine cancer risk in patients with serrated polyposis syndrome (SPS) and their relatives as well as patients
Asking Patients With Colorectal Cancer to Help Get Their Siblings Screened Is Not That Helpful
We often tell our patients with colorectal cancer (CRC) or advanced adenomas that guidelines indicate their siblings are at increased risk of developing CRC or
U.S. Multi-Society Task Force Endorses Colorectal Cancer Screening in Average-Risk Persons at Age 45
In a recommendation characterized as “weak recommendation; low-quality evidence,” the U.S. Multi-Society Task Force on Colorectal Cancer (MSTF) now recommends initiating screening for colorectal cancer
Patients Live a Healthier Lifestyle After Endoscopic Screening
Previous studies have been inconclusive as to whether endoscopic screening contributes to patients leading a healthier or unhealthier lifestyle. For example, patients with normal examinations
Protein Assays Added to the Fecal Immunochemical Test Improve Sensitivity for Advanced Adenomas
The fecal immunochemical test (FIT) is widely chosen by organized colorectal cancer (CRC) screening programs as the screening test of choice. FIT detects about 80%
Strong Evidence That Long-Term Proton Pump Inhibitor Use Increases Colorectal Cancer Risk
Data vary regarding whether hypergastrinemia and proton pump inhibitor (PPI) use increase adenoma progression and risk of colorectal cancer (CRC). The current study from the
Colonoscopy More Effective Than the Fecal Immunochemical Test in Case-Control Study
Randomized controlled trials comparing the use of colonoscopy to the fecal immunochemical test (FIT) for colorectal cancer (CRC) screening are underway. A case-control study from
Yes, Early Onset Colorectal Adenocarcinoma Rates Are Increasing, But Rectal Carcinoid Rates Are Increasing Faster
There is now widespread recognition that there are increasing rates of colorectal cancer in persons under age 50 (early-onset colorectal cancer), that most of the
Patients With Multifocal Cancer: Evidence for Intraluminal Spread of Tumor
In various series, 2% to 7% of patients with colorectal cancer (CRC) have either synchronous or metachronous second cancer. Second CRCs have generally been considered
Non-White Race and Low Socioeconomic Status Associated With Longer Wait for Treatment After Colorectal Cancer Diagnosis
The time between diagnosis of colorectal cancer (CRC) and initiation of treatment is associated with mortality. In this study of 330,988 CRC cases in the
Randomized Trial of Sequential Testing Versus Multiple Choices for CRC Screening
Many guidelines on colorectal cancer (CRC) screening advocate that the choice of screening tests should be based on a discussion between the provider and patient