{"id":9807,"date":"2021-01-21T15:42:16","date_gmt":"2021-01-21T14:42:16","guid":{"rendered":"https:\/\/www.endoscopy-campus.com\/?post_type=ec-news&#038;p=9807"},"modified":"2021-01-21T15:42:17","modified_gmt":"2021-01-21T14:42:17","slug":"depressed-lesions-are-different-at-a-histologic-and-molecular-level","status":"publish","type":"ec-news","link":"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/depressed-lesions-are-different-at-a-histologic-and-molecular-level\/","title":{"rendered":"Depressed Lesions Are Different at a Histologic and Molecular Level"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">In a study from Japan, T1 colorectal cancers and adenomas were classified as \u201cdepressed,\u201d \u201cflat,\u201d or \u201cprotruded\u201d subtypes. Depressed lesions constituted only 1.2% of all neoplasms, but 66% of the depressed lesions were cancerous compared to 2.6% each with the other two lesion subtypes. Compared to nondepressed carcinomas, depressed T1 cancers were less likely to have residual adenoma, more likely to have deep submucosal or lymphovascular invasion, and more likely to have a recurrence or distant metastasis. Depressed adenomas were considerably more likely than flat or protruded adenomas to have high-grade dysplasia.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Depressed adenomas, however, were much less likely than nondepressed adenomas to express <em>KRAS<\/em> mutations.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a study from Japan, T1 colorectal cancers and adenomas were classified as \u201cdepressed,\u201d \u201cflat,\u201d or \u201cprotruded\u201d subtypes. Depressed lesions constituted only 1.2% of all neoplasms, but 66% of the depressed lesions were cancerous compared to 2.6% each with the other two lesion subtypes. Compared to nondepressed carcinomas, depressed T1 cancers were less likely to &#8230; <a title=\"Depressed Lesions Are Different at a Histologic and Molecular Level\" class=\"read-more\" href=\"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/depressed-lesions-are-different-at-a-histologic-and-molecular-level\/\" aria-label=\"Read more about Depressed Lesions Are Different at a Histologic and Molecular Level\">Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1769],"tags":[2598,2599,72],"class_list":["post-9807","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-asge-kolon","tag-depressed-lesions","tag-depressed-t1-cancers","tag-kolon"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/9807","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=9807"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=9807"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=9807"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}