Swallowed topical corticosteroids (STC) are effective as initial treatment in patients with eosinophilic esophagitis (EoE) and in achieving histological remission. However, their role in the long-term management of EoE is not clear. <\/p>\n\n\n\n
This multicenter observational study of 5 centers in the U.S. and Switzerland reported the effectiveness and safety of patients receiving \u22640.5 mg fluticasone or budesonide (low-dose STC) or >0.5 mg (high-dose STC) for a primary outcome of histological relapse (\u226515 eosinophils per high-power field [eos\/hpf]) after at least 1 follow-up endoscopy. Of 82 patients included in the study, 58 received low-dose STC and 24 were treated with high-dose STC. The majority of patients (93%) were treated with twice-daily dosing. Despite achieving initial histological remission (<15 eos\/hpf), 45 of these patients had ongoing EoE-related symptoms, 11 of whom required endoscopic dilation for symptoms, including dysphagia, bolus impaction, and stricture. In addition, histological relapse occurred in 67% of the overall treated patients (72%, low-dose STC; 54%, high-dose STC). Relapse occurred significantly earlier in the low-dose STC group at 1-year follow-up versus 1.8-year follow-up for the high-dose STC recipients. Esophageal candidiasis was documented in 6% of the treated patients with no significant difference between treatment groups.<\/p>\n","protected":false},"excerpt":{"rendered":"
Swallowed topical corticosteroids (STC) are effective as initial treatment in patients with eosinophilic esophagitis (EoE) and in achieving histological remission. However, their role in the long-term management of EoE is not clear. This multicenter observational study of 5 centers in the U.S. and Switzerland reported the effectiveness and safety of patients receiving \u22640.5 mg fluticasone … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1791],"tags":[299,2098,2142],"class_list":["post-9054","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-esophagus","tag-eoe","tag-esophagus-2","tag-stc"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/9054","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=9054"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=9054"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=9054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}