Eosinophilic esophagitis (EoE) is a chronic antigen-mediated immunological disorder that has a high relapse rate of >80% with cessation of therapy. Although corticosteroids (both topical and oral) are used in the acute setting and remission can be achieved, long-term data are lacking.<\/p>\n\n\n\n
This randomized controlled study aimed to investigate the efficacy and safety of a budesonide orodispersible tablet (BOT) for sustained remission (fulfilling all of the following: no clinical or histological relapse, no food impaction requiring intervention, no need for dilation, and no premature withdrawal for any reason) of EoE in patients at 48 weeks. A total of 204 patients who achieved clinical-histopathological remission after 6 to 12 weeks of BOT treatment were randomized to receive 1 mg or 2 mg BOT, or placebo. Concurrent proton pump inhibitor treatment was maintained. Sustained remission after 48 weeks of treatment was achieved in 73.5%, 75%, and 4.4% of patients in the 1-mg BOT, 2-mg BOT, and placebo groups, respectively (P<\/em><.001). At the end of treatment, histological (peak \u226548 eosinophils\/mm^2 high-power field) and clinical relapse (dysphagia or odynophagia with severity \u22644 points on a 0-10 point numerical rating scale) rates occurred significantly less in the study treatment groups compared to placebo. There were no serious drug-related adverse events. Oral candidiasis occurred in 10% to 15% of patients treated with BOT, whereas morning cortisol remained stable compared to baseline.<\/p>\n","protected":false},"excerpt":{"rendered":" Eosinophilic esophagitis (EoE) is a chronic antigen-mediated immunological disorder that has a high relapse rate of >80% with cessation of therapy. Although corticosteroids (both topical and oral) are used in the acute setting and remission can be achieved, long-term data are lacking. This randomized controlled study aimed to investigate the efficacy and safety of a … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1791],"tags":[2130,299,2129,2098],"class_list":["post-8942","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-esophagus","tag-bot","tag-eoe","tag-eosinophilic-esophagitis-2","tag-esophagus-2"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/8942","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=8942"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=8942"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=8942"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}