The incidence of eosinophilic esophagitis (EoE), a condition characterized by esophageal eosinophilia and dysfunction, has been reported in about 5 to 10 per 100,000 individuals. Interestingly, northern Denmark, with a population of about 580,000, recorded only as many as 4 cases annually until 2010. In September 2011, a meeting was held in Denmark to reach a consensus on biopsy and pathology reporting protocols. This publication is a retrospective evaluation of the EoE cohorts before and after the meeting (2007-2017).<\/p>\n\n\n\n
The attendees of the consensus meeting, which was attended by 82% of the invited endoscopy leaders, concluded that they would obtain esophageal biopsies using the \u201c4-14-4 rule\u201d (4 biopsies from 14 cm and 4 cm above the gastroesophageal junction) and that pathologists would report when eosinophilia \u2013 especially \u226515 eosinophils per high-power field \u2013 was present. These centralized pathology reports would link to the regional EoE guideline. Educational information and a summary of the consensus reached was distributed to all endoscopy centers in the North Denmark Region via short lectures and emails to all endoscopy unit directors. <\/p>\n\n\n\n
According to Denmark\u2019s national pathology registry, 309 patients (229 males [median age, 50 years]; 80 females [median age, 47 years]) were diagnosed with EoE from 2007 through 2017. While there were only 9 patients in the database prior to the consensus meeting (2007-2010), the number increased to 294 after the meeting (2012-2017). Of the 309 patients in the registry, 74% were categorized as having EoE and 24% had GERD. The new protocol resulted in a 12-fold increase in the median number of patients diagnosed with EoE per year (0.4\/100,000 [2007-2010] to 6.2\/100,000 [2012-2017]). Overall, the frequency of esophageal eosinophilia diagnoses increased 50-fold from the earlier time period of 2001 to 2010 (1\/year; 0.2\/100,000) to the later time period of 2010 to 2017 (52\/year; 8.9\/100,000). There was a 14% increase in the number of upper endoscopies and a 100% increase in the frequency of biopsies performed after the meeting compared to before the meeting.<\/p>\n","protected":false},"excerpt":{"rendered":"
The incidence of eosinophilic esophagitis (EoE), a condition characterized by esophageal eosinophilia and dysfunction, has been reported in about 5 to 10 per 100,000 individuals. Interestingly, northern Denmark, with a population of about 580,000, recorded only as many as 4 cases annually until 2010. In September 2011, a meeting was held in Denmark to reach … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1791],"tags":[299,2098],"class_list":["post-8884","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-esophagus","tag-eoe","tag-esophagus-2"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/8884","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=8884"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=8884"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=8884"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}