Given the paucity of high-quality outcome data, the optimal management of polypoid and\/or nonpolypoid colonic lesions in IBD is an ongoing debate. Guidelines recommend that dysplasia with distinct margins be considered for endoscopic resection, followed by close colonoscopic surveillance. <\/p>\n\n\n\n
The authors conducted a meta-analysis of 18 studies involving 1037 patients (933 with ulcerative colitis) with a total of 1428 lesions endoscopically resected from the colon who were followed for a mean duration ranging from 6 months to 82 months. The pooled risk of colorectal cancer (CRC) and high-grade dysplasia (HGD) was estimated to be 2 per 1000 person-years of follow-up. The incidence and\/or recurrence rate of any lesion was 43 per 1000 person-years, with one-third of lesions managed endoscopically. Lesion location (right, left), size, type (Paris-I, Paris-II), or histology (low-grade dysplasia [LGD], HGD) and endoscopic resection technique (EMR, ESD, or traditional polypectomy) did not influence the pooled outcomes of any neoplasia. While lesion characteristics did not significantly impact CRC risk, there were trends toward significance with left-sided lesions (P<\/em>=.06) and lesion size (P<\/em>=.06), supporting the notion that left-sided lesions, as well as large lesions, are more prone to malignant conversion. There were also trends toward significance with both LGD (P<\/em>=.06) and HGD (P<\/em>=.09), supporting the hypothesis that tumor progression in an inflammatory bowel segment does not necessarily follow the LGD to HGD to cancer pathway. The rate of adverse events was low at 2% for each bleeding and perforating complication.<\/p>\n","protected":false},"excerpt":{"rendered":" Given the paucity of high-quality outcome data, the optimal management of polypoid and\/or nonpolypoid colonic lesions in IBD is an ongoing debate. Guidelines recommend that dysplasia with distinct margins be considered for endoscopic resection, followed by close colonoscopic surveillance. The authors conducted a meta-analysis of 18 studies involving 1037 patients (933 with ulcerative colitis) with … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1790],"tags":[1343,268,267,2114,1875,2115],"class_list":["post-8851","ec-news","type-ec-news","status-publish","hentry","category-ibd","tag-crc","tag-emr","tag-esd","tag-hgd","tag-ibd-2","tag-lgd"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/8851","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=8851"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=8851"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=8851"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}