Granular laterally spreading tumors (G-LST) in the colorectum are more common than nongranular lesions, less likely to have cancer, and in general, easier to remove because of a lower prevalence of submucosal fibrosis. However, within the granular group, lesions with a discrete large nodule, often called \u201cmixed nodular\u201d or \u201cGM-LST,\u201d have a higher risk of cancer. In any LST with a substantial risk of submucosal invasive cancer (SMIC), the rationale for en bloc resection increases because patients with only superficial invasion (<1000 microns) and no other unfavorable histologic features may be able to avoid surgery after en bloc resection. <\/p>\n\n\n\n
In a multicenter Italian study, 693 lesions with GM-LST morphology were prospectively assessed. The overall risk of covert SMIC was 9.5%. Two-thirds of the lesions with covert SMIC were in the rectum, and two-thirds were \u22654 cm in size. The overall risk of covert SMIC in rectal lesions \u22654 cm in size was 22%. Thus, the number needed to treat (NNT) to remove one lesion with SMIC in that group was 5. For lesions either above the rectum or <4 cm in size, the NNT to remove one lesion with covert SMIC ranged from 13 to 20.<\/p>\n","protected":false},"excerpt":{"rendered":"
Granular laterally spreading tumors (G-LST) in the colorectum are more common than nongranular lesions, less likely to have cancer, and in general, easier to remove because of a lower prevalence of submucosal fibrosis. However, within the granular group, lesions with a discrete large nodule, often called \u201cmixed nodular\u201d or \u201cGM-LST,\u201d have a higher risk of … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1769],"tags":[2058,2110,2111,72,24],"class_list":["post-8831","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-asge-kolon","tag-colon-2","tag-g-lst","tag-gm-lst","tag-kolon","tag-lst"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/8831","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=8831"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=8831"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=8831"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}