Upper endoscopy (EGD) with biopsy remains the gold standard for the diagnosis of Barrett\u2019s esophagus (BE). Several nonendoscopic techniques (sponge, capsule) have utilized biomarkers, such as protein markers, microRNAs, and methylated DNA markers, as screening tools for BE. This multicenter case-control study was designed to evaluate the accuracy of a sponge-on-string device (EsophaCap, Capnostics, Pa) for BE diagnosis.<\/p>\n\n\n\n
A total of 112 BE cases (\u22651 cm of circumferential BE with intestinal metaplasia; median age, 66 years; 82% male; median BE segment length, C4M6; 49% no dysplasia; and 19% esophageal adenocarcinoma) were compared with 89 controls (no endoscopic evidence of BE; median age, 59 years; 47% male). <\/p>\n\n\n\n
All participants swallowed the sponge, which was withdrawn after 8 minutes, and underwent subsequent EGD. DNA extracted from the sponge device was then subjected to methylation studies. Of the several methylated DNA markers tested, 5 (VAV3, ZNF682, NDRG4, FER1L4, and ZNF568) were selected using a cross-validated method for BE prediction. The sensitivity of these 5 markers was 92% (95% confidence interval [CI], 85%\u201396%) and the specificity was 94% (95% CI, 87%\u201398%), with an overall area under the curve of 0.97 (95% CI, 0.93-0.99). There was no significant difference in the sensitivity for BE without dysplasia (89%; 95% CI, 77%\u201396%) compared with BE with any grade of dysplasia (95%; 95% CI, 85%\u201399%) (P<\/em>=.16). The prediction model was not affected by age, sex, body mass index, or smoking status, but it was influenced by BE length (4 cases of short-segment BE missed; P<\/em><.0001). Complications with the device included technical issues (5 patients), intolerance\/premature withdrawal <5 minutes (4 patients), or tether detachment (1 patient).<\/p>\n","protected":false},"excerpt":{"rendered":" Upper endoscopy (EGD) with biopsy remains the gold standard for the diagnosis of Barrett\u2019s esophagus (BE). Several nonendoscopic techniques (sponge, capsule) have utilized biomarkers, such as protein markers, microRNAs, and methylated DNA markers, as screening tools for BE. This multicenter case-control study was designed to evaluate the accuracy of a sponge-on-string device (EsophaCap, Capnostics, Pa) … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1791],"tags":[1944,1929,1601],"class_list":["post-8823","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-esophagus","tag-barretts-esophagus-2","tag-be","tag-egd-2"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/8823","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=8823"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=8823"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=8823"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}