Radiofrequency ablation (RFA) is a widely used modality for treating flat Barrett\u2019s esophagus (BE) dysplasia, with the goal of achieving complete eradication of intestinal metaplasia (CE-IM). However, some patients do not achieve CE-IM despite multiple RFA sessions. Volumetric laser endomicroscopy (VLE) is a technology that provides visualization of the superficial layers of the esophageal wall. This retrospective VLE registry-based study evaluated whether thickness of the BE epithelium was a determinant of treatment response, CE-IM, or strictures after RFA.\u00a0<\/p>\n\n\n\n
A total of 61 patients with a mean age of 63.5 years, median Prague classification length of C1M3, and mean BE thickness of 408.2 micrometers, who had a baseline VLE scan followed by RFA for BE, were included in the analysis. It was noted that every 100-micrometer increase in mean thickness of BE was associated with a 12% decrease (95% confidence interval, -24% to -1%) in response (reduction of Prague M length) after RFA. The mean BE thickness was lower for the CE-IM group at 394.8 micrometers (standard deviation [SD], 121.7 micrometers) than the non-CE-IM group at 428.4 micrometers (SD, 88.9 micrometers), but this was not statistically significant (P<\/em>=.11). Similarly, BE thickness was also higher in the 6 patients who had strictures (483.4 micrometers; SD, 96.7 micrometers) as compared to those who did not (402.8 micrometers; SD, 105.3 micrometers;\u00a0P<\/em>=.065).<\/p>\n","protected":false},"excerpt":{"rendered":" Radiofrequency ablation (RFA) is a widely used modality for treating flat Barrett\u2019s esophagus (BE) dysplasia, with the goal of achieving complete eradication of intestinal metaplasia (CE-IM). However, some patients do not achieve CE-IM despite multiple RFA sessions. Volumetric laser endomicroscopy (VLE) is a technology that provides visualization of the superficial layers of the esophageal wall. … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1791],"tags":[2083,1040,2084,2085],"class_list":["post-8734","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-esophagus","tag-barretts-esophagus-thickness","tag-rfa","tag-vle-scan","tag-volumetric-laser-endomicroscopy"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/8734","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=8734"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=8734"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=8734"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}