{"id":8733,"date":"2020-07-23T13:36:00","date_gmt":"2020-07-23T11:36:00","guid":{"rendered":"https:\/\/www.endoscopy-campus.com\/?post_type=ec-news&#038;p=8733"},"modified":"2020-07-26T13:43:05","modified_gmt":"2020-07-26T11:43:05","slug":"relapse-half-as-likely-with-ulcerative-colitis-in-clinical-and-endoscopic-remission-than-clinical-remission-with-mild-endoscopic-disease-activity","status":"publish","type":"ec-news","link":"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/relapse-half-as-likely-with-ulcerative-colitis-in-clinical-and-endoscopic-remission-than-clinical-remission-with-mild-endoscopic-disease-activity\/","title":{"rendered":"Relapse Half as Likely With Ulcerative Colitis in Clinical and Endoscopic Remission Than Clinical Remission with Mild Endoscopic Disease Activity"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">The current treatment target in ulcerative colitis (UC) is clinical and endoscopic remission, defined by patient-reported outcomes and a Mayo endoscopic subscore of 0 or 1. In this systemic review and meta-analysis of 17 studies and 2608 adult patients, the authors evaluated whether achievement of a subscore of 0 and histologic remission would result in lower annual clinical relapse rates.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The authors estimated that among patients with UC in clinical remission, those with endoscopically healed mucosa (defined as a Mayo endoscopic subscore of 0) were 52% less likely to experience a flare within 12 months compared to those with evidence of mild disease activity (Mayo endoscopic subscore 1; relative risk, 0.48; 95% confidence interval, 0.37\u20130.62). The annual rate of UC flare decreased from 29% (Mayo endoscopic subscore of 1) to 14% (Mayo endoscopic subscore of 0). When histologic remission was achieved, the risk of relapse further decreased to 5%. Since most studies included the meta-analysis\u2013combined medications, the authors were unable to ascertain whether the magnitude of benefit may be different in patients treated with 5-aminosalicylic acid medications versus immunosuppressives, including biologics and targeted small molecule inhibitors.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The current treatment target in ulcerative colitis (UC) is clinical and endoscopic remission, defined by patient-reported outcomes and a Mayo endoscopic subscore of 0 or 1. In this systemic review and meta-analysis of 17 studies and 2608 adult patients, the authors evaluated whether achievement of a subscore of 0 and histologic remission would result in &#8230; <a title=\"Relapse Half as Likely With Ulcerative Colitis in Clinical and Endoscopic Remission Than Clinical Remission with Mild Endoscopic Disease Activity\" class=\"read-more\" href=\"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/relapse-half-as-likely-with-ulcerative-colitis-in-clinical-and-endoscopic-remission-than-clinical-remission-with-mild-endoscopic-disease-activity\/\" aria-label=\"Read more about Relapse Half as Likely With Ulcerative Colitis in Clinical and Endoscopic Remission Than Clinical Remission with Mild Endoscopic Disease Activity\">Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1790],"tags":[2082,1942],"class_list":["post-8733","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-ibd","tag-mayo-endoscopic-subscore","tag-ulcerative-colitis-2"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/8733","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=8733"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=8733"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=8733"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}