Alterations of the gut microbiota in irritable bowel syndrome (IBS) have been described. Observational studies on fecal microbiota transplantation (FMT) aiming to restore eubiosis have described symptomatic improvement in patients with IBS, but results from randomized controlled trials (RCTs) have been inconsistent. A meta-analysis of 4 previously published RCTs concluded that FMT was not beneficial in improving global IBS symptom scores. Subgroup analyses suggested that patients with IBS and diarrhea or mixed bowel habits might respond better to FMT than constipated patients with IBS; nasojejunal or colonoscopic delivery might be more efficacious than capsules; and finding a single \u201csuper donor\u201d versus pooling stool from different donors might be the best option. <\/p>\n\n\n\n
In this RCT from Norway, 165 patients with IBS received either 30 g or 60 g of frozen stool from a healthy super donor or autologous stool (placebo) that was delivered to the duodenum via upper endoscopy. At 3 months, a greater percentage of patients responded in both the 60-g and 30-g FMT groups than in the placebo group (89%, 77%, and 24%, respectively; P<\/em><.0001 for both). A significantly higher number of patients with any of the 3 subtypes of IBS reported improvements in abdominal symptoms and quality of life after receiving FMT compared to placebo recipients. The microbiome of the patients who underwent FMT changed; however, the dysbiosis index did not decrease significantly. Mild, self-limited adverse events (abdominal discomfort, diarrhea, constipation, nausea) occurred in up to 25% of FMT recipients.<\/p>\n","protected":false},"excerpt":{"rendered":" Alterations of the gut microbiota in irritable bowel syndrome (IBS) have been described. Observational studies on fecal microbiota transplantation (FMT) aiming to restore eubiosis have described symptomatic improvement in patients with IBS, but results from randomized controlled trials (RCTs) have been inconsistent. A meta-analysis of 4 previously published RCTs concluded that FMT was not beneficial … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1790],"tags":[1875,1883,2055],"class_list":["post-8165","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-ibd","tag-ibd-2","tag-ibs","tag-rct"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/8165","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=8165"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=8165"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=8165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}