Colorectal cancer (CRC) screening can be offered to patients as a menu of screening options; sequential testing (colonoscopy offered first with another testing option offered when colonoscopy is refused); or a risk-stratified approach, in which colonoscopy is offered to high-risk patients and fecal immunochemical testing (FIT) is offered to low-risk patients. Thus far, no randomized controlled trial (RCT) has evaluated the risk-stratified approach. <\/p>\n\n\n\n
In a trial from China, 19,546 persons aged 50 to 74 years were randomized into 3 groups: one-time colonoscopy, annual FIT, or risk-adapted screening. The cutoff for positive FIT was 4 \u00b5g Hgb\/g feces, resulting in a positive FIT rate of 14%. Risk was assigned based on the Asia-Pacific Colorectal Screening score, which uses age, gender, CRC history in first-degree relatives, smoking, and body mass index. In the risk arm, 18.9% of patients were assessed as high risk.<\/p>\n\n\n\n
Overall participation rates in the colonoscopy, FIT, and risk arms were 42.5%, 94%, and 85.2%, respectively. On an intent-to-screen basis, CRC rates were 0.23%, 0.09%, and 0.17%, respectively. Advanced adenoma rates were 2.17%, 1.04%, and 1.49%, respectively. The numbers of colonoscopies to detect one advanced neoplasm were 18, 10, and 11, respectively.<\/p>\n","protected":false},"excerpt":{"rendered":"
Colorectal cancer (CRC) screening can be offered to patients as a menu of screening options; sequential testing (colonoscopy offered first with another testing option offered when colonoscopy is refused); or a risk-stratified approach, in which colonoscopy is offered to high-risk patients and fecal immunochemical testing (FIT) is offered to low-risk patients. Thus far, no randomized … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1769],"tags":[2028,1343],"class_list":["post-7837","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-asge-kolon","tag-colorectal-cancer-screening","tag-crc"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/7837","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=7837"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=7837"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=7837"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}