{"id":7429,"date":"2020-03-09T06:49:49","date_gmt":"2020-03-09T05:49:49","guid":{"rendered":"https:\/\/www.endoscopy-campus.com\/?post_type=ec-news&#038;p=7429"},"modified":"2020-03-09T06:49:50","modified_gmt":"2020-03-09T05:49:50","slug":"meta-analysis-associates-helicobacter-pylori-infection-with-colorectal-neoplasia","status":"publish","type":"ec-news","link":"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/meta-analysis-associates-helicobacter-pylori-infection-with-colorectal-neoplasia\/","title":{"rendered":"Meta-analysis Associates Helicobacter pylori Infection With Colorectal Neoplasia"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><em><strong>Douglas K. Rex, MD, FASGE, reviewing Choi DS, et al. Clin Transl Gastroenterol 2020 Feb.<\/strong><\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Helicobacter pylori<\/em>&nbsp;(<em>H. pylori<\/em>) infection has been previously associated with colorectal neoplasia, presumably via mechanisms of hypergastrinemia or intestinal dysbiosis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In an up-to-date meta-analysis involving 48 studies and 171,045 patients, the odds ratios (ORs) for adenoma, advanced adenoma, and colorectal cancer with&nbsp;<em>H. pylori<\/em>&nbsp;infection were all increased at 1.49, 1.50, and 1.44, respectively. After adjustment for publication bias in the adenoma estimate, the risk remained increased with an OR of 1.39.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-pullquote\" style=\"border-color:#bd6fb7\"><blockquote><p> COMMENT<br>Many of the studies in the meta-analysis were small and with large effect sizes, and some were low quality. Nevertheless, the available evidence continues to indicate the real possibility that\u00a0<em>H. pylori<\/em>\u00a0infection is associated with an increased risk of colorectal neoplasia.<\/p><\/blockquote><\/figure>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Note to readers: At the time we reviewed this paper, its publisher noted that it was not in final form and that subsequent changes might be made. <\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide\" style=\"grid-template-columns:27% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"188\" src=\"https:\/\/www.endoscopy-campus.com\/wp-content\/uploads\/d-rex.jpg\" alt=\"\" class=\"wp-image-5921\"\/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"has-large-font-size wp-block-paragraph\">Douglas K. Rex, MD, FASGE <\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">CITATION(S) <\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Choi DS, Seo SI, Shin WG, Park CH. Risk for colorectal neoplasia in patients with\u00a0<em>Helicobacter pylori<\/em>\u00a0infection: a systematic review and meta-analysis.\u00a0<em>Clin Transl Gastroenterol<\/em>\u00a02020;11:e00127. (<a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.14309\/ctg.0000000000000127\" target=\"_blank\">https:\/\/doi.org\/10.14309\/ctg.0000000000000127<\/a>)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Douglas K. Rex, MD, FASGE, reviewing Choi DS, et al. Clin Transl Gastroenterol 2020 Feb. Helicobacter pylori&nbsp;(H. pylori) infection has been previously associated with colorectal neoplasia, presumably via mechanisms of hypergastrinemia or intestinal dysbiosis. In an up-to-date meta-analysis involving 48 studies and 171,045 patients, the odds ratios (ORs) for adenoma, advanced adenoma, and colorectal cancer &#8230; <a title=\"Meta-analysis Associates Helicobacter pylori Infection With Colorectal Neoplasia\" class=\"read-more\" href=\"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/meta-analysis-associates-helicobacter-pylori-infection-with-colorectal-neoplasia\/\" aria-label=\"Read more about Meta-analysis Associates Helicobacter pylori Infection With Colorectal Neoplasia\">Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1769],"tags":[1926,1925],"class_list":["post-7429","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-asge-kolon","tag-h-pylori","tag-helicobacter-pylori"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/7429","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=7429"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=7429"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=7429"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}