{"id":7343,"date":"2020-02-24T12:46:06","date_gmt":"2020-02-24T11:46:06","guid":{"rendered":"https:\/\/www.endoscopy-campus.com\/?post_type=ec-news&#038;p=7343"},"modified":"2020-02-24T12:46:07","modified_gmt":"2020-02-24T11:46:07","slug":"berberine-reduces-metachronous-colorectal-adenomas-in-randomized-trial","status":"publish","type":"ec-news","link":"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/berberine-reduces-metachronous-colorectal-adenomas-in-randomized-trial\/","title":{"rendered":"Berberine Reduces Metachronous Colorectal Adenomas in Randomized Trial"},"content":{"rendered":"\n<p><em><strong>Douglas K. Rex, MD, FASGE, reviewing Chen YX, et al. Lancet Gastroenterol Hepatol 2020 Jan 8.<\/strong><\/em><\/p>\n\n\n\n<p>Berberine is a Chinese herbal extract used to treat diarrhea and enteritis and is widely sold (including in the U.S.) as a dietary supplement. There is some evidence it can block tumorigenesis. About 1100 Chinese patients with a history of colorectal adenomas were randomized to receive 0.3 grams of berberine twice daily or placebo in a double-blind trial. Patients underwent colonoscopy one year after enrollment, and if they had no adenomas at the one-year follow-up, a second colonoscopy was performed at two years.&nbsp;<\/p>\n\n\n\n<p>At the end of two years of follow-up, 36% of 429 berberine recipients who had completed follow-up had developed adenomas compared to 47% of patients in the placebo group (relative risk, 0.77;<em>\u00a0P<\/em>=.001). Advanced adenomas were found in 3% of the berberine group and 6% of the placebo group (<em>P<\/em>=.05). There was no difference in side effects, with about 1% of berberine patients developing constipation.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-pullquote\" style=\"border-color:#bd6fb7\"><blockquote><p> COMMENT<br>On the internet, berberine is promoted as a relatively inexpensive dietary supplement that treats metabolic syndrome, diabetes, and lipid elevation. Its most common side effects are GI related and are reversible with cessation. Now there is evidence from a randomized controlled trial that berberine reduces adenoma recurrence. Given the safety profile and low cost, it seems to be a reasonable option to discuss with high-risk adenoma patients interested in reducing polyp and cancer risk.<\/p><\/blockquote><\/figure>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Note to readers: At the time we reviewed this paper, its publisher noted that it was not in final form and that subsequent changes might be made. <\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide\" style=\"grid-template-columns:27% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"188\" src=\"https:\/\/www.endoscopy-campus.com\/wp-content\/uploads\/d-rex.jpg\" alt=\"\" class=\"wp-image-5921\"\/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"has-large-font-size\">Douglas K. Rex, MD, FASGE <\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">CITATION(S) <\/h2>\n\n\n\n<p>Chen YX, Gao QY, Zou TH, et al. Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study.\u00a0<em>Lancet Gastroenterol Hepatol<\/em>\u00a02020 Jan 8. (Epub ahead of print) (<a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1016\/S2468-1253(19)30409-1\" target=\"_blank\">https:\/\/doi.org\/10.1016\/S2468-1253(19)30409-1<\/a>) <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Douglas K. Rex, MD, FASGE, reviewing Chen YX, et al. Lancet Gastroenterol Hepatol 2020 Jan 8. Berberine is a Chinese herbal extract used to treat diarrhea and enteritis and is widely sold (including in the U.S.) as a dietary supplement. There is some evidence it can block tumorigenesis. About 1100 Chinese patients with a history &#8230; <a title=\"Berberine Reduces Metachronous Colorectal Adenomas in Randomized Trial\" class=\"read-more\" href=\"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/berberine-reduces-metachronous-colorectal-adenomas-in-randomized-trial\/\" aria-label=\"Read more about Berberine Reduces Metachronous Colorectal Adenomas in Randomized Trial\">Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1769],"tags":[1900],"class_list":["post-7343","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-asge-kolon","tag-berberine"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/7343","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=7343"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=7343"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=7343"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}