According to data, 1.5% of the U.S. population has hereditary breast and ovarian cancer syndrome (0.72%), Lynch syndrome (0.35%), or familial hypercholesterolemia (FH; 0.43%).<\/p>\n\n\n\n
This study modeled population-based genomic testing for all 3 syndromes using a single (hypothetical) test in multiple hypothetical cohorts between the ages of 20 and 60 that were representative of the U.S. population. Assumptions included a $250 multigene panel test; costs for testing, such as mammography, magnetic resonance imaging, and colonoscopy; costs of treatment, such as prophylactic surgeries; the likelihood of pre-existing knowledge of a mutation; 70% likelihood that identified probands would inform at-risk family members; and 20% of informed family members would receive testing. The investigators compared the results and costs of simultaneous genomic testing to usual care.<\/p>\n\n\n\n
The model found that screening 100,000 unselected 30-year-old patients prevented 45 cases of breast cancer, 8 cases of ovarian cancer, 48 cases of colorectal cancer (CRC), 9 myocardial infarctions (MIs), and 6 strokes. The model was most sensitive to the genetic testing cost, the relative risk for MI in FH probands, prior MI in FH probands, 5-year survival in breast cancer, and CRC stage at diagnosis. <\/p>\n\n\n\n
Sensitivity analyses indicated screening 30-year-olds had a 99.4% probability of being cost-effective at a $100,000 per quality-adjusted life-year threshold. The incremental cost-effectiveness ratio for screening 30-year-olds reached $100,000 at a test cost of $413. Screening at age 40 or 50 was less cost-effective.<\/p>\n","protected":false},"excerpt":{"rendered":"
According to data, 1.5% of the U.S. population has hereditary breast and ovarian cancer syndrome (0.72%), Lynch syndrome (0.35%), or familial hypercholesterolemia (FH; 0.43%). This study modeled population-based genomic testing for all 3 syndromes using a single (hypothetical) test in multiple hypothetical cohorts between the ages of 20 and 60 that were representative of the … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1769],"tags":[2058,1861,3739],"class_list":["post-14231","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-asge-kolon","tag-colon-2","tag-lynch-syndrome","tag-simultaneous-population-based-testing"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/14231","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=14231"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=14231"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=14231"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}