Peroral endoscopic myotomy (POEM) is increasingly being used as mainline therapy for patients with achalasia. After POEM, approximately 30% to 50% of patients experience abnormal esophageal acid exposure, whereas 10% have symptomatic gastroesophageal reflux disease (GERD) and erosive esophagitis. <\/p>\n\n\n\n
This study aimed to evaluate the efficacy of endoscopic full-thickness plication (EFTP) in treating GERD after POEM through a randomized sham-controlled trial involving 60 patients. The primary endpoint was an improvement in acid exposure time (AET) below 6%, and secondary endpoints included improvements in esophagitis, GERD questionnaire (GERDQ) scores, and proton pump inhibitor (PPI) usage. <\/p>\n\n\n\n
At 3 months, 69% of patients in the EFTP group achieved improvement in AET below 6%, which was significantly more than the 10.3% of patients who achieved this in the sham group. EFTP was also statistically superior to the sham procedure in improving esophageal AET, DeMeester Scores, and all reflux episodes (P<\/em><.001). Median scores at 3 and 6 months were significantly better in the EFTP group (P<\/em><.001), and a higher proportion of patients in the sham group versus the EFTP group continued to use PPIs (72% vs 28%). No major adverse events were reported in either group.<\/p>\n","protected":false},"excerpt":{"rendered":" Peroral endoscopic myotomy (POEM) is increasingly being used as mainline therapy for patients with achalasia. After POEM, approximately 30% to 50% of patients experience abnormal esophageal acid exposure, whereas 10% have symptomatic gastroesophageal reflux disease (GERD) and erosive esophagitis. This study aimed to evaluate the efficacy of endoscopic full-thickness plication (EFTP) in treating GERD after … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1791],"tags":[2766,3690,2098,2070,2578,237],"class_list":["post-14026","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-esophagus","tag-eftp","tag-endoscopic-full-thickness-plication","tag-esophagus-2","tag-gerd-2","tag-peroral-endoscopic-myotomy-2","tag-poem"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/14026","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=14026"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=14026"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=14026"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}