Malignant gastric outlet obstruction (GOO) has a profound negative impact on quality of life (QoL). Options for palliation include surgical gastroenterostomy, enteral stent placement, and, most recently, endoscopic ultrasound-guided gastroenterostomy (EUS-GE). This multicenter prospective trial primarily aimed to study the impact of EUS-GE on patient QoL. Secondary outcomes were all-cause mortality, readmission, and adverse event rates.<\/p>\n\n\n\n
Sixty-four patients with unresectable malignant GOO who underwent EUS-GE between August 2019 and May 2021 at 4 Spanish centers were prospectively enrolled. Thirty-three patients were male (51.6%), and the etiology of GOO in most patients was secondary to pancreatic (35.9%) or gastric (31.3%) cancer. <\/p>\n\n\n\n
The European Organization for Research and Treatment of Cancer (EORTC) questionnaire EORTC-QLQ-C30 was used to assess patients at baseline and 1 month after the procedure. Patients received follow-up telephone calls at inclusion and 1, 7, and 30 days after EUS-GE. The Gastric Outlet Obstruction Scoring System (GOOSS) was used to evaluate oral intake, with clinical success defined as a GOOSS \u22652. A linear mixed model assessed differences between baseline and 30-day QoL scores. <\/p>\n\n\n\n
Most patients (n=61, 95.3%) restarted oral intake within 48 hours, and the median postprocedure hospital stay was 3.5 days (interquartile range, 2-5). The 30-day clinical success rate was 83.3%. There was a clinically significant increase of 21.6 points (95% confidence interval, 11.5-31.7) in the global health status scale, with significant improvements in symptoms. Adverse events occurred in 10 patients (15.6%): 6 were self-limiting, 3 required endoscopic reintervention, and 1 patient died.<\/p>\n","protected":false},"excerpt":{"rendered":"
Malignant gastric outlet obstruction (GOO) has a profound negative impact on quality of life (QoL). Options for palliation include surgical gastroenterostomy, enteral stent placement, and, most recently, endoscopic ultrasound-guided gastroenterostomy (EUS-GE). This multicenter prospective trial primarily aimed to study the impact of EUS-GE on patient QoL. Secondary outcomes were all-cause mortality, readmission, and adverse event … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,2052],"tags":[3648,3650,3649,625,3211,2522,3645,3647,3646],"class_list":["post-13892","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-eus","tag-endoscopic-ultrasound-guided-gastroenterostomy","tag-eortc","tag-european-organization-for-research-and-treatment-of-cancer","tag-eus","tag-eus-ge","tag-goo","tag-malignant-gastric-outlet-obstruction","tag-qol","tag-quality-of-life"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/13892","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=13892"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=13892"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=13892"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}