{"id":13552,"date":"2022-12-28T17:06:27","date_gmt":"2022-12-28T16:06:27","guid":{"rendered":"https:\/\/www.endoscopy-campus.com\/?post_type=ec-news&#038;p=13552"},"modified":"2022-12-28T17:06:29","modified_gmt":"2022-12-28T16:06:29","slug":"randomized-controlled-trial-shows-hemostatic-peptide-solution-tdm-621-reduces-need-for-coagulation-forceps-treatment-during-esd-by-80","status":"publish","type":"ec-news","link":"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/randomized-controlled-trial-shows-hemostatic-peptide-solution-tdm-621-reduces-need-for-coagulation-forceps-treatment-during-esd-by-80\/","title":{"rendered":"Randomized Controlled Trial Shows Hemostatic Peptide Solution TDM-621 Reduces Need for Coagulation Forceps Treatment During ESD by 80%"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Bleeding can be problematic during endoscopic submucosal dissection (ESD). The bleeding point may be difficult to identify, and coagulation may lead to muscle injury and perforation.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In a multicenter randomized controlled trial from Japan, patients undergoing gastric or rectal ESD who had bleeding occur during ESD were randomized to treatment with coagulation forceps first versus instillation of the peptide solution TDM-621, followed by coagulation if the bleeding persisted after 3 minutes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In the primary endpoint, the number of coagulation-forcep treatments per case was 4.9 without TDM-621 and 1.0 with TDM-621. Hemostasis was achieved with TDM-621 without using electrocautery in 62% of cases, and the mean dose of TDM-621 was 1.75 mL. The time to achieve hemostasis was longer with TDM-621 than without (210 vs 93 seconds). There was no difference in adverse events between arms.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bleeding can be problematic during endoscopic submucosal dissection (ESD). The bleeding point may be difficult to identify, and coagulation may lead to muscle injury and perforation.&nbsp; In a multicenter randomized controlled trial from Japan, patients undergoing gastric or rectal ESD who had bleeding occur during ESD were randomized to treatment with coagulation forceps first versus &#8230; <a title=\"Randomized Controlled Trial Shows Hemostatic Peptide Solution TDM-621 Reduces Need for Coagulation Forceps Treatment During ESD by 80%\" class=\"read-more\" href=\"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/randomized-controlled-trial-shows-hemostatic-peptide-solution-tdm-621-reduces-need-for-coagulation-forceps-treatment-during-esd-by-80\/\" aria-label=\"Read more about Randomized Controlled Trial Shows Hemostatic Peptide Solution TDM-621 Reduces Need for Coagulation Forceps Treatment During ESD by 80%\">Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1769],"tags":[2058,785,267,3553,3554],"class_list":["post-13552","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-asge-kolon","tag-colon-2","tag-endoscopic-submucosal-dissection","tag-esd","tag-hemostatic-peptide-solution","tag-tdm"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/13552","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=13552"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=13552"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=13552"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}