In the first report of incidence and mortality results from a randomized controlled trial (RCT) comparing colonoscopy with no screening, 84,585 previously unscreened persons aged 55 to 64 years old were randomized to an invitation for colonoscopy versus usual care (no invitation) in a 1:2 ratio between 2009 and 2014. The study results are from Norway, Poland, and Sweden and have a median follow-up of 10 years.<\/p>\n\n\n\n
In the group invited to undergo colonoscopy, 42% underwent screening. There were no perforations or screening-related deaths after colonoscopy.<\/p>\n\n\n\n
On an intent-to-screen basis, the reduction in colorectal cancer (CRC) incidence was 18% in the invited group compared with the usual-care group. In the invited group, the risk of death from CRC was reduced by only 10%, and the difference did not reach significance.<\/p>\n\n\n\n
In the per-protocol analysis, the reduction in CRC incidence was 31% and the reduction in CRC death was 50%. For uncertain reasons, the incidence reduction was 45% in Norway and 15% in Poland.<\/p>\n\n\n\n
The fraction of cancers in the screen-detected group that were early stage was similar to that of the usual-care group.<\/p>\n\n\n\n
The overall adenoma detection rate (ADR) was 30.7%, with no report of adenomas per colonoscopy. There was no analysis of reductions in proximal versus distal cancer incidence.<\/p>\n","protected":false},"excerpt":{"rendered":"
In the first report of incidence and mortality results from a randomized controlled trial (RCT) comparing colonoscopy with no screening, 84,585 previously unscreened persons aged 55 to 64 years old were randomized to an invitation for colonoscopy versus usual care (no invitation) in a 1:2 ratio between 2009 and 2014. The study results are from … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1769],"tags":[2470,1933,2058,1823,1343,2645,2055],"class_list":["post-13042","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-asge-kolon","tag-adenoma-detection-rate-2","tag-adr-2","tag-colon-2","tag-colorectal-cancer","tag-crc","tag-randomized-controlled-trial","tag-rct"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/13042","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=13042"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=13042"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=13042"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}