This is a post hoc analysis of a risk-stratification screening strategy based on the Asia-Pacific Colorectal Screening (APCS) scoring system. This score ranks patients as high, moderate, or low risk for colorectal cancer (CRC) or advanced neoplasia based on age, sex, family history of CRC in a first-degree relative, and smoking status.<\/p>\n\n\n\n
A total of 2240 patients underwent colonoscopy, of whom 38.8% were classified as high risk according to the APCS scoring system and, therefore, would go directly to colonoscopy. With the remaining low- and moderate-risk patients, investigators evaluated the performance of a fecal immunochemical test (FIT) at cutoffs of 20 \u00b5g Hb\/g stool and 4.4 \u00b5g Hb\/g stool and a stool DNA test developed in China.<\/p>\n\n\n\n
The high-risk patients were more likely to have advanced neoplasia (20.1% vs 12.2%). The combined sensitivity of the APCS score with the stool DNA test for advanced neoplasms was 73.5%, which was higher than the APCS score combined with FIT at both the 20 \u00b5g cutoff (62.8% sensitivity) and the 4.4 \u00b5g cutoff (68% sensitivity). <\/p>\n\n\n\n
The combination of this specific DNA test plus FIT did not alter test specificity. All the strategies had high sensitivity for cancer: 95.2% for the APCS score plus the stool DNA test, 90.5% for the APCS score plus FIT at 4.4 \u00b5g, and 88.1% for the APCS score plus FIT at 20 \u00b5g.<\/p>\n\n\n\n
The strategy of the APCS score plus the stool DNA test reduced overall colonoscopy use by 53%.<\/p>\n","protected":false},"excerpt":{"rendered":"
This is a post hoc analysis of a risk-stratification screening strategy based on the Asia-Pacific Colorectal Screening (APCS) scoring system. This score ranks patients as high, moderate, or low risk for colorectal cancer (CRC) or advanced neoplasia based on age, sex, family history of CRC in a first-degree relative, and smoking status. A total of … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1769],"tags":[3440,3439,2058,1823,1343,3441,1826,1898],"class_list":["post-12954","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-asge-kolon","tag-apcs","tag-asia-pacific-colorectal-screening","tag-colon-2","tag-colorectal-cancer","tag-crc","tag-dna","tag-fecal-immunochemical-test","tag-fit"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/12954","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=12954"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=12954"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=12954"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}