The use of proton pump inhibitors (PPIs) has continually increased over the past 20 to 30 years. As a result, interest has grown in the possible association of PPIs with adverse events and even mortality. This prospective cohort study used data from the Nurses\u2019 Health Study (2004-2018) and the Health Professionals Follow-up Study (2004-2018). It used a modified lag-time approach to study the association between PPI use and mortality. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality according to PPI use. <\/p>\n\n\n\n
For the study, 50,156 women and 21,731 men were followed for 832,026 person-years and a median of 13.8 years. There were 22,125 deaths: 4592 from cancer, 5404 from cardiovascular diseases, and 12,129 from other causes. PPI users had significantly higher risks of all-cause mortality and mortality due to cancer, cardiovascular diseases, respiratory diseases, and digestive diseases than nonusers of PPIs. <\/p>\n\n\n\n
After applying lag-times of up to 6 years, the associations were no longer statistically significant (all-cause: HR, 1.04; 95% CI, 0.97-1.11; cancer: HR, 1.07; 95% CI, 0.89-1.28; cardiovascular diseases: HR, 0.94; 95% CI, 0.81-1.10; respiratory diseases: HR, 1.20; 95% CI, 0.95-1.50; and digestive diseases: HR, 1.38; 95% CI, 0.88-2.18). There was increased mortality due to renal disease (HR, 2.45; 95% CI, 1.59-3.78). However, there was a lack of information on potential cofounders. Therefore, long-term PPI use was not associated with higher risks of all-cause and cause-specific mortality.<\/p>\n","protected":false},"excerpt":{"rendered":"
The use of proton pump inhibitors (PPIs) has continually increased over the past 20 to 30 years. As a result, interest has grown in the possible association of PPIs with adverse events and even mortality. This prospective cohort study used data from the Nurses\u2019 Health Study (2004-2018) and the Health Professionals Follow-up Study (2004-2018). It … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1789],"tags":[3374,3373,3371,3372,3203,2629,2103],"class_list":["post-12395","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-stomach-and-small-bowel","tag-cis","tag-confidence-intervals","tag-hazard-ratios","tag-hrs","tag-ppis","tag-proton-pump-inhibitors","tag-stomach-2"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/12395","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=12395"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=12395"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=12395"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}