Anal cancer is 10 times more common in HIV-positive men than cervical cancer is in women in the general population; however, women with HIV are also at increased risk of anal cancer. <\/p>\n\n\n\n
In this trial, patients diagnosed with HIV were screened for high-grade squamous intraepithelial lesions (HSILs) using high-resolution anoscopy. Biopsy-confirmed HSILs were identified in 55.1% of men, 47.2% of women, and 67.1% of transgender persons. Among the demographic characteristics of patients with HSILs who were randomized to the trial: median age of 51 years, living with HIV for a median of 17 years, 80% male gender identity, 42% Black, 77% male-to-male sexual contact, and 33% current smokers. <\/p>\n\n\n\n
Patients were randomized to active treatment of HSILs, which was mostly by office-based ablative techniques such as electrocautery (but could include excision under anesthesia or application of topical agents like fluorouracil), versus active monitoring for development of cancer. <\/p>\n\n\n\n
High-resolution endoscopy was performed at least every 6 months, and 21 cases of anal cancer developed in the active-monitoring group versus 9 in the treatment group, for a 57% reduction in risk (P<\/em>=.03).<\/p>\n","protected":false},"excerpt":{"rendered":" Anal cancer is 10 times more common in HIV-positive men than cervical cancer is in women in the general population; however, women with HIV are also at increased risk of anal cancer. In this trial, patients diagnosed with HIV were screened for high-grade squamous intraepithelial lesions (HSILs) using high-resolution anoscopy. Biopsy-confirmed HSILs were identified in … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1769],"tags":[3349,2058,3350,1780,3351],"class_list":["post-12364","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-asge-kolon","tag-anal-cancer","tag-colon-2","tag-high-grade-squamous-intraepithelial-lesions","tag-hiv","tag-hsils"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/12364","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=12364"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=12364"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=12364"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}