{"id":12340,"date":"2022-06-27T14:59:27","date_gmt":"2022-06-27T12:59:27","guid":{"rendered":"https:\/\/www.endoscopy-campus.com\/?post_type=ec-news&#038;p=12340"},"modified":"2022-06-27T14:59:28","modified_gmt":"2022-06-27T12:59:28","slug":"12-of-12-patients-with-mismatch-repair-deficient-locally-advanced-rectal-cancer-had-complete-response-to-dostarlimab-alone","status":"publish","type":"ec-news","link":"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/12-of-12-patients-with-mismatch-repair-deficient-locally-advanced-rectal-cancer-had-complete-response-to-dostarlimab-alone\/","title":{"rendered":"12 of 12 Patients With Mismatch Repair-Deficient, Locally Advanced Rectal Cancer Had Complete Response to Dostarlimab Alone"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">It is well known that mismatch repair-deficient colorectal cancer (CRC), also called microsatellite instability (MSI)-high CRC, fails to respond to traditional fluorouracil-based chemotherapy but has substantial response rates to programmed cell death (PD)-1 blockade, also called immune checkpoint inhibitor therapy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This study examined the response to a PD-1 blocker in 12 patients with locally advanced rectal cancer and confirmed MSI-high tumors. None of the tumors had&nbsp;<em>BRAF<\/em>&nbsp;mutations, indicating they did not arise through the serrated pathway, and most had germline mutations in Lynch genes, though none of the patients had a family history of Lynch syndrome.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">All 12 patients had a complete response to dostarlimab after 6 months of therapy, as judged by rectal magnetic resonance imaging, 18F-fluorodeoxyglucose\u2013positron-emission tomography, digital rectal examination, and endoscopic biopsies. Side effects were not severe and consisted of rash, dermatitis, pruritis, fatigue, and nausea.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>It is well known that mismatch repair-deficient colorectal cancer (CRC), also called microsatellite instability (MSI)-high CRC, fails to respond to traditional fluorouracil-based chemotherapy but has substantial response rates to programmed cell death (PD)-1 blockade, also called immune checkpoint inhibitor therapy. This study examined the response to a PD-1 blocker in 12 patients with locally advanced &#8230; <a title=\"12 of 12 Patients With Mismatch Repair-Deficient, Locally Advanced Rectal Cancer Had Complete Response to Dostarlimab Alone\" class=\"read-more\" href=\"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/12-of-12-patients-with-mismatch-repair-deficient-locally-advanced-rectal-cancer-had-complete-response-to-dostarlimab-alone\/\" aria-label=\"Read more about 12 of 12 Patients With Mismatch Repair-Deficient, Locally Advanced Rectal Cancer Had Complete Response to Dostarlimab Alone\">Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1769],"tags":[2058,1823,1343,3336,3337],"class_list":["post-12340","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-asge-kolon","tag-colon-2","tag-colorectal-cancer","tag-crc","tag-microsatellite-instability","tag-msi"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/12340","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=12340"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=12340"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=12340"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}