{"id":12223,"date":"2022-05-16T17:07:10","date_gmt":"2022-05-16T15:07:10","guid":{"rendered":"https:\/\/www.endoscopy-campus.com\/?post_type=ec-news&#038;p=12223"},"modified":"2022-05-16T17:07:11","modified_gmt":"2022-05-16T15:07:11","slug":"multi-society-task-force-issues-new-recommendations-for-management-of-hamartomatous-polyposis-syndromes","status":"publish","type":"ec-news","link":"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/multi-society-task-force-issues-new-recommendations-for-management-of-hamartomatous-polyposis-syndromes\/","title":{"rendered":"Multi-Society Task Force Issues New Recommendations for Management of Hamartomatous Polyposis Syndromes"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">The hamartomatous polyposis syndromes include Peutz-Jeghers syndrome, juvenile polyposis syndrome,&nbsp;<em>PTEN<\/em>&nbsp;hamartoma tumor syndrome (Cowden\u2019s and Bannayan-Riley-Ruvalcaba syndromes), and hereditary mixed polyposis syndrome. This document is a highly informative treatise on the topic. Some key recommendations from a new consensus statement released by the U.S. Multi-Society Task Force on Colorectal Cancer include:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Peutz-Jeghers syndrome (PJS)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Test for&nbsp;<em>STK11<\/em>&nbsp;in anyone with \u22652 confirmed Peutz-Jeghers (PJ) polyps, any PJ polyps and a family history of PJS in a first-degree relative (FDR), mucocutaneous pigmentation and a family history of PJS, or any PJ polyps and characteristic mucocutaneous pigmentation.<\/li><li>Use a multidisciplinary approach because PJS requires screening for breast, small bowel, colon, stomach, pancreas, ovarian, testes, and lung cancers.<\/li><li>Perform video capsule endoscopy or magnetic resonance enterography screening for small bowel polyps beginning at ages 8 to 10 years, or sooner if the patient is symptomatic. Repeat testing every 2 to 3 years if any polyps are detected, or resume testing at age 18 if there are no polyps at baseline testing.<\/li><li>Complete EGD and colonoscopy every 2 to 3 years, depending on the polyp burden.<\/li><li>Perform polypectomy when small bowel polyps are symptomatic or \u226510 mm to prevent intussusception and bleeding.<\/li><li>Begin annual MRCP or EUS screening for pancreatic cancer at age 35.<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Juvenile polyposis syndrome<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sequence&nbsp;<em>SMAD4<\/em>&nbsp;and&nbsp;<em>BMPR1A<\/em>&nbsp;if there are \u22655 juvenile polyps in the colon or rectum, \u22652 juvenile polyps in other GI sections, or any juvenile polyps and an FDR with JPS.<\/li><li>Perform EGD and colonoscopy every 1 to 3 years, beginning at ages 12 to 15, with the interval depending on the polyp burden.&nbsp;<\/li><li>Screen patients with&nbsp;<em>SMAD4<\/em>&nbsp;for hereditary hemorrhagic telangiectasia.<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>PTEN<\/em>&nbsp;hamartoma tumor syndrome<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Screen for&nbsp;<em>PTEN<\/em>&nbsp;if there are multiple hamartomas or ganglioneuromas.<\/li><li>Use a multidisciplinary approach because patients with this syndrome are at risk for breast, thyroid, kidney, uterus, colon, and skin cancers.<\/li><li>Begin colonoscopy screening at age 35 or at the age 10 years younger than the youngest diagnosed relative, with an interval of 5 years or less, depending on the polyp burden.<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Hereditary mixed polyposis syndrome<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Too few data are available to establish the best colonoscopy surveillance practice.<\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>The hamartomatous polyposis syndromes include Peutz-Jeghers syndrome, juvenile polyposis syndrome,&nbsp;PTEN&nbsp;hamartoma tumor syndrome (Cowden\u2019s and Bannayan-Riley-Ruvalcaba syndromes), and hereditary mixed polyposis syndrome. This document is a highly informative treatise on the topic. Some key recommendations from a new consensus statement released by the U.S. Multi-Society Task Force on Colorectal Cancer include: Peutz-Jeghers syndrome (PJS) Test for&nbsp;STK11&nbsp;in &#8230; <a title=\"Multi-Society Task Force Issues New Recommendations for Management of Hamartomatous Polyposis Syndromes\" class=\"read-more\" href=\"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/multi-society-task-force-issues-new-recommendations-for-management-of-hamartomatous-polyposis-syndromes\/\" aria-label=\"Read more about Multi-Society Task Force Issues New Recommendations for Management of Hamartomatous Polyposis Syndromes\">Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1769],"tags":[2058,3286,3287,3284,3285],"class_list":["post-12223","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-asge-kolon","tag-colon-2","tag-cowdens-and-bannayan-riley-ruvalcaba-syndromes","tag-hamartoma-tumor-syndrome","tag-hamartomatous-polyposis-syndromes","tag-peutz-jeghers-syndrome"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/12223","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=12223"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=12223"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=12223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}