{"id":12190,"date":"2022-05-05T17:18:41","date_gmt":"2022-05-05T15:18:41","guid":{"rendered":"https:\/\/www.endoscopy-campus.com\/?post_type=ec-news&#038;p=12190"},"modified":"2022-05-05T17:18:42","modified_gmt":"2022-05-05T15:18:42","slug":"what-are-the-long-term-outcomes-of-gastric-peroral-endoscopic-myotomy-performed-for-gastroparesis","status":"publish","type":"ec-news","link":"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/what-are-the-long-term-outcomes-of-gastric-peroral-endoscopic-myotomy-performed-for-gastroparesis\/","title":{"rendered":"What Are the Long-Term Outcomes of Gastric Peroral Endoscopic Myotomy Performed for Gastroparesis?"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Refractory gastroparesis (RG) negatively impacts the quality of life, and treatments to date have worked variably. Gastric peroral endoscopic myotomy (G-POEM), first performed in 2013, appears to have good early success in the treatment of RG; however, data on long-term clinical success are unknown. This retrospective study of data collected from a prospective cohort of patients who underwent G-POEM for RG evaluates the efficacy of G-POEM after 4 years of follow-up. Secondary endpoints included safety, quality of life, clinical success among the different etiologies of RG, and predictive factors for success.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Between April 2017 and December 2021, this study evaluated the outcomes of 374 patients with RG who underwent G-POEM. The etiologies of gastroparesis included 141 (37.7%) diabetic (DG); 115 (30.7%) idiopathic (IG); 102 (27.3%) postsurgical (PSG); and 16 (4.3%) other etiologies. The Gastroparesis Cardinal Symptom Index (GCSI), retention percentage at 4 hours (RP4H), mean half-emptying time (MHET), and short-form surveys (SF-36) were performed at 1, 6, 12, 18, 24, 30, 36, 42, and 48 months.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">One hundred two patients completed follow-up at 48 months (DG=58, IG=22, PSG=18, and others=4). Among the improvements from before G-POEM to the 48-month post\u2013G-POEM evaluation:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>GCSI improved from 3.84\u00b10.53 to 2.1\u00b10.70 (<em>P<\/em>&lt;.001).<\/li><li>RP4H improved from 44% (11%-68%) to 15.5% (0%-36%) (P=.021).<\/li><li>MHET improved from 246 minutes (150-368) to 135 minutes (67-290) (<em>P<\/em>=.045).&nbsp;<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Among other findings:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Clinical success was 77.5% at 48 months and was most successful when DG was the etiology (DG=86.5% vs IG=72.5% [<em>P<\/em>=.001]; vs PSG=72.1% [<em>P<\/em>=.003] and other=68.8% [<em>P<\/em>&lt;.001]).&nbsp;<\/li><li>Predictors of long-term success were DG as the etiology (odds ratio [OR], 5.113; 95% confidence interval [CI], 1.643-5.981;&nbsp;<em>P<\/em>=.035), early diagnosis (OR, 2.455; 95% CI, 1.129-3.522;&nbsp;<em>P<\/em>=.042), presence of nausea and\/or vomiting (OR, 3.541; 95% CI, 1.881-5.511;&nbsp;<em>P<\/em>=.012), GCSI (1.5-2) and RP4H &lt;10% at 6 months (OR, 3.612; 95% CI, 2.122-5.317;&nbsp;<em>P<\/em>=.022 and OR, 2.188; 95% CI, 1.435-4.233;&nbsp;<em>P<\/em>=.039, respectively).<\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Refractory gastroparesis (RG) negatively impacts the quality of life, and treatments to date have worked variably. Gastric peroral endoscopic myotomy (G-POEM), first performed in 2013, appears to have good early success in the treatment of RG; however, data on long-term clinical success are unknown. This retrospective study of data collected from a prospective cohort of &#8230; <a title=\"What Are the Long-Term Outcomes of Gastric Peroral Endoscopic Myotomy Performed for Gastroparesis?\" class=\"read-more\" href=\"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/what-are-the-long-term-outcomes-of-gastric-peroral-endoscopic-myotomy-performed-for-gastroparesis\/\" aria-label=\"Read more about What Are the Long-Term Outcomes of Gastric Peroral Endoscopic Myotomy Performed for Gastroparesis?\">Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1789],"tags":[595,3273,3059,3272,2103],"class_list":["post-12190","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-stomach-and-small-bowel","tag-g-poem","tag-gastric-peroral-endoscopic-myotomy-2","tag-refractory-gastroparesis","tag-rg","tag-stomach-2"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/12190","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=12190"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=12190"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=12190"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}