Individuals diagnosed with head and neck squamous cell carcinoma (HNSCC) are known to have an increased risk of developing a second primary tumor in the esophagus. This single-center study from the Netherlands identified patients diagnosed with HNSCC to determine the incidence, risk factors, and survival of those found to have a second primary esophageal tumor. <\/p>\n\n\n\n
Of the 1708 patients (66.2% male; mean age, 64.4 [11.5] years) with pathology-confirmed HNSCC, 484 (28.3%) underwent an endoscopy after diagnosis, and 47 were found to have a second primary esophageal tumor (SCC, 43; adenocarcinoma, 4). The cumulative incidence of being diagnosed with a second primary esophageal tumor was 2.9% at 10 years. The median time from HNSCC to esophageal tumor diagnosis was 18 months, and 32% (n=15) were identified within 6 months from the original HNSCC diagnosis. The features that significantly increased the risk for a second primary esophageal tumor were HNSCC location (in the oral cavity, hypopharynx, or oropharynx) and consumption of more than 2 standard drinks of alcohol per day. The overall survival was decreased when patients were found to have a second primary esophageal tumor (hazard ratio, 3.36; 95% confidence interval, 2.16-5.22) compared with those without an esophageal tumor.<\/p>\n","protected":false},"excerpt":{"rendered":"
Individuals diagnosed with head and neck squamous cell carcinoma (HNSCC) are known to have an increased risk of developing a second primary tumor in the esophagus. This single-center study from the Netherlands identified patients diagnosed with HNSCC to determine the incidence, risk factors, and survival of those found to have a second primary esophageal tumor. … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1791],"tags":[2098,3228,3227,3226],"class_list":["post-12039","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-esophagus","tag-esophagus-2","tag-head-and-neck-squamous-cell-carcinoma","tag-hnscc","tag-screening-endoscopy"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/12039","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=12039"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=12039"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=12039"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}