The incidence of celiac disease has been increasing over time and is commonly encountered in GI practice. Although a gluten-free diet leads to pathologic disease remission, symptoms may persist in a subset of patients. A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) is recommended for patients with irritable bowel syndrome (IBS). However, its efficacy in patients with celiac disease is not well established. This randomized controlled trial, performed from October 2018 to August 2019, assessed the efficacy of a low FODMAP diet on alleviating symptoms in patients with treated celiac disease with ongoing GI symptoms. <\/p>\n\n\n\n
Seventy patients with biopsy-proven celiac disease were enrolled in the study and randomized to a low FODMAP diet (n=34) or a control group (n=36). All 70 patients had persistent gastrointestinal symptoms, defined by a score \u226530 on the IBS version of the Gastrointestinal Symptom Rating Scale (GSRS-IBS), gluten-free diet adherence \u226512 months, as well as serological and biopsy-proven remission. GSRS-IBS was recorded at baseline and weeks 1 to 4, and the Celiac Symptom Index (CSI) score was recorded at baseline and week 4. <\/p>\n\n\n\n
GSRS-IBS total scores differed significantly between the groups (P<\/em><0.001 for interaction) starting as soon as one week (mean difference [95% confidence interval\/CI] of intervention vs control (-8.2 [-11.5, -5.0]) and persisting through week 4 (-10.8 [-14.8, -6.8]). Additionally, the intervention group experienced significant improvements in pain, bloating, diarrhea, and satiety (P<\/em>\u22640.04 for interaction) but not constipation (P<\/em>=0.43 for interaction). CSI was significantly lower in the intervention group versus the control group at week 4 (mean difference, -5.8; 95% CI [-9.6, -2.0]).<\/p>\n","protected":false},"excerpt":{"rendered":" The incidence of celiac disease has been increasing over time and is commonly encountered in GI practice. Although a gluten-free diet leads to pathologic disease remission, symptoms may persist in a subset of patients. A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) is recommended for patients with irritable bowel syndrome (IBS). However, … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1789],"tags":[509,3179,2103],"class_list":["post-11888","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-stomach-and-small-bowel","tag-celiac-disease","tag-fodmap","tag-stomach-2"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/11888","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=11888"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=11888"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=11888"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}