{"id":11699,"date":"2022-02-17T11:39:52","date_gmt":"2022-02-17T10:39:52","guid":{"rendered":"https:\/\/www.endoscopy-campus.com\/?post_type=ec-news&#038;p=11699"},"modified":"2022-02-17T11:39:53","modified_gmt":"2022-02-17T10:39:53","slug":"oral-microbiome-therapy-made-of-purified-firmicutes-spores-effective-for-treatment-of-recurrent-c-difficile-infection","status":"publish","type":"ec-news","link":"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/oral-microbiome-therapy-made-of-purified-firmicutes-spores-effective-for-treatment-of-recurrent-c-difficile-infection\/","title":{"rendered":"Oral Microbiome Therapy Made of Purified Firmicutes Spores Effective for Treatment of Recurrent\u00a0C difficile\u00a0Infection"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">This study was a double-blind, randomized, placebo-controlled trial. It included patients with \u22653 episodes of&nbsp;<em>C difficile<\/em>&nbsp;infection (CDI) within 12 months, including the qualifying acute episode. Patients with proven active, recurrent CDI were treated with fidaxomicin or vancomycin with symptom resolution followed by 4 doses of SER-109 (purified Firmicutes spores) or placebo. They were also given 10 ounces of magnesium citrate to drink the night before starting SER-109 or placebo treatment to protect ingested spores from antibiotics. Patients were followed up to 8 weeks after treatment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The incidence of subsequent recurrence was 12% with SER-109 and 40% with placebo, and the number needed to treat was 3.6. SER-109 was effective in all age groups regardless of antibiotic treatment with vancomycin or fidaxomicin. There were no significant adverse events.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This study was a double-blind, randomized, placebo-controlled trial. It included patients with \u22653 episodes of&nbsp;C difficile&nbsp;infection (CDI) within 12 months, including the qualifying acute episode. Patients with proven active, recurrent CDI were treated with fidaxomicin or vancomycin with symptom resolution followed by 4 doses of SER-109 (purified Firmicutes spores) or placebo. They were also given &#8230; <a title=\"Oral Microbiome Therapy Made of Purified Firmicutes Spores Effective for Treatment of Recurrent\u00a0C difficile\u00a0Infection\" class=\"read-more\" href=\"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/oral-microbiome-therapy-made-of-purified-firmicutes-spores-effective-for-treatment-of-recurrent-c-difficile-infection\/\" aria-label=\"Read more about Oral Microbiome Therapy Made of Purified Firmicutes Spores Effective for Treatment of Recurrent\u00a0C difficile\u00a0Infection\">Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1769],"tags":[3175,1874,2058,3174,3176],"class_list":["post-11699","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-asge-kolon","tag-c-difficile-infection","tag-cdi","tag-colon-2","tag-oral-microbiome-therapy","tag-ser-109"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/11699","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=11699"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=11699"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=11699"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}