The incidence of esophageal adenocarcinoma (EAC) continues to increase and is still associated with a poor prognosis with a 5-year survival rate of 20%. The majority of EAC cases are found during index endoscopic screening of the upper GI tract; therefore, screening for EAC and its precursor lesion, Barrett\u2019s esophagus (BE), could potentially impact EAC rates. <\/p>\n\n\n\n
This systematic review included 14 studies of endoscopic and pathologically confirmed cases of BE or EAC in patients with a positive family history (N=16,189). The overall pooled prevalence of family history was higher in patients with BE (8.8%; 95% confidence interval [CI], 5.5%-13.8%; I2<\/em>=76%; 6 studies) than patients with EAC (4.4%; 95% CI, 2.2%-8.7%; I2<\/em>=75%; 7 studies). When first-degree relatives of patients with BE underwent endoscopic screening, the yield for BE was between 12% and 44% (4 studies) but was low for high-grade dysplasia and EAC (<2%). Finally, individuals with a family history had a higher risk of being diagnosed with BE (adjusted relative risk [aRR], 3.26; 95% CI, 1.43-7.40) and EAC (aRR, 2.19; 95% CI, 1.14-4.21) compared with individuals without a family history.<\/p>\n","protected":false},"excerpt":{"rendered":" The incidence of esophageal adenocarcinoma (EAC) continues to increase and is still associated with a poor prognosis with a 5-year survival rate of 20%. The majority of EAC cases are found during index endoscopic screening of the upper GI tract; therefore, screening for EAC and its precursor lesion, Barrett\u2019s esophagus (BE), could potentially impact EAC … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1791],"tags":[1944,1929,2138,2975,2098],"class_list":["post-11026","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-esophagus","tag-barretts-esophagus-2","tag-be","tag-eac","tag-esophageal-adenocarcinoma","tag-esophagus-2"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/11026","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=11026"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=11026"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=11026"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}