Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer mortality since most cancers are advanced at diagnosis. Early identification of these cancers is essential. This case-control study aimed to describe glycemic and weight changes that occur before PDAC diagnosis in a diverse population. <\/p>\n\n\n\n
Cases of PDAC at a tertiary care institution between January 2011 and November 2019 were matched with controls in a 1:2 fashion (1542 cases:3084 controls). The median age was 69.3 years, 2487 patients (53.8%) were male, and 751 (48.7%) were non-Hispanic White. Study periods were 54 to 66 months, 42 to 54 months, 30 to 42 months, 18 to 30 months, 6 to 18 months, and 0 to 6 months before PDAC diagnosis. Comparison of cases and controls at each study interval was performed using t<\/em> tests for normally distributed variables and the Wilcoxon rank sum test for variables not normally distributed. Logistic regression was used to estimate odds of PDAC based on changes over time in hemoglobin A1c (HbA1c) and body mass index (BMI), controlling for appropriate confounders. <\/p>\n\n\n\n HbA1c was higher in PDAC cases than controls (P<\/em>\u2264.02 for all) in the 3 years before diagnosis. For all study periods, BMI was greater for PDAC cases, except 0 to 6 months before cancer diagnosis when BMI was lower (P<\/em><.01 for all). The BMI change in cases 1 year and 6 months before diagnosis was -0.59 and -1.21 (P<\/em><.01) when compared with -0.08 and 0.03 for controls (P<\/em><.01), respectively. After adjusting for race, smoking, alcohol use, sex, and age, multivariate logistic regression demonstrated that HbA1c slope (adjusted odds ratio [aOR], 1.33; 95% confidence interval [CI], 1.01-1.76) and BMI slope (aOR, 0.75; 95% CI, 0.65-0.87) were predictors of PDAC.<\/p>\n","protected":false},"excerpt":{"rendered":" Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer mortality since most cancers are advanced at diagnosis. Early identification of these cancers is essential. This case-control study aimed to describe glycemic and weight changes that occur before PDAC diagnosis in a diverse population. Cases of PDAC at a tertiary care institution between January … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,67],"tags":[2936,2934,2128,2935],"class_list":["post-10858","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-bauchspeicheldruese-pankreas","tag-pancreatic-cancer","tag-pancreatic-ductal-adenocarcinoma","tag-pancreatobiliary","tag-pdac"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/10858","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=10858"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=10858"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=10858"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}