Those at high risk or with a prior history of esophageal squamous cell cancer (SCC) are recommended to undergo screening or surveillance using dye-based chromoendoscopy. Lugol\u2019s iodine has been the go-to solution for performing chromoendoscopy, with nearly 100% sensitivity for detecting dysplastic lesions. More recently, narrow-band imaging (NBI) has been proposed as an alternate due to the ease of use and lack of adverse events related to dye spraying. <\/p>\n\n\n\n
This multicenter, prospective, randomized, controlled trial included patients from 15 centers in France from multiple endoscopy settings, including tertiary referral centers, local hospitals, and private clinics. A total of 334 patients were randomized to either white-light endoscopy (WLE) plus Lugol chromoendoscopy (n=167; 91% male) or WLE plus NBI (n=167; 86.8% male) followed by Lugol chromoendoscopy (as the gold standard). <\/p>\n\n\n\n
There were 106 suspicious lesions detected in the Lugol group, and 18 were histologically defined as dysplastic (14 cancers, 1 high-grade dysplasia [HGD], 3 low-grade dysplasia [LGD]). Of these, 11 lesions were identified during WLE, and 7 additional lesions were detected following Lugol staining. In the NBI group, 61 suspicious lesions were identified, 22 of which were SCC by histology. Lugol chromoendoscopy performed after NBI identified 9 additional neoplastic lesions (2 SCC, 2 HGD, 5 LGD). Using per-patient analysis, the sensitivity of Lugol was 100% (76.8%-100%), specificity 66.0% (57.9%-73.5%), positive predictive value (PPV) 21.2% (12.1%-33.0%), and negative predictive value (NPV) 100% (96.4%-100%). The sensitivity of NBI was 100% (81.5%-100%), specificity 79.9% (72.5%-86.0%), PPV 37.5% (24.0%-52.6%), and NPV 100% (96.9%-100%). The difference in specificity between the 2 arms was clinically significant (P<\/em>=.002), and there was no significant difference in the incidence, size, or extent of dysplasia between the 2 groups.<\/p>\n","protected":false},"excerpt":{"rendered":" Those at high risk or with a prior history of esophageal squamous cell cancer (SCC) are recommended to undergo screening or surveillance using dye-based chromoendoscopy. Lugol\u2019s iodine has been the go-to solution for performing chromoendoscopy, with nearly 100% sensitivity for detecting dysplastic lesions. More recently, narrow-band imaging (NBI) has been proposed as an alternate due … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1791],"tags":[2098,2904,280,1432,2905],"class_list":["post-10762","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-esophagus","tag-esophagus-2","tag-narrow-band","tag-nbi","tag-scc-2","tag-squamous-cell-cancer"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/10762","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=10762"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=10762"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=10762"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}