In 2020, the U.S. Food and Drug Administration and other similar bodies recalled all ranitidine products, secondary to a possible increased association with several types of cancers. Although the exact reason for this is unknown, the carcinogen N-nitrosodimethylamine is higher in ranitidine users, especially in their urine. This nested case-control trial using a Scottish database aimed to investigate whether ranitidine use is associated with an increased risk of bladder cancer.<\/p>\n\n\n\n
Between 1999 and 2011, bladder cancer cases were identified and matched with up to 5 controls (based on age, sex, general practice, and date of registration). A review of prescribing records identified the use of ranitidine, other histamine-2 receptor agonists, and proton pump inhibitors (PPIs) among patients. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression after adjusting for comorbidities and smoking. <\/p>\n\n\n\n
There were 3260 bladder cancer cases and 14,037 controls that met inclusion criteria. Current or former smoking rates were higher in the bladder cancer group than the control group (26.1% vs 21.0%); however, alcohol use and comorbidities were similar. There was an increased risk of bladder cancer in ranitidine users compared with nonusers (fully adjusted OR, 1.22; 95% CI, 1.06-1.40), which increased with more than 3 years of ranitidine use (fully adjusted OR, 1.43; 95% CI, 1.05-1.94). Conversely, there was little evidence of any association between PPI use and bladder cancer risk based on any ranitidine use (fully adjusted OR, 0.98; 95% CI, 0.88-1.11) or more than 3 years of use (fully adjusted OR, 0.98; 95% CI, 0.80-1.20).<\/p>\n","protected":false},"excerpt":{"rendered":"
In 2020, the U.S. Food and Drug Administration and other similar bodies recalled all ranitidine products, secondary to a possible increased association with several types of cancers. Although the exact reason for this is unknown, the carcinogen N-nitrosodimethylamine is higher in ranitidine users, especially in their urine. This nested case-control trial using a Scottish database … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1789],"tags":[2802,2610,2103],"class_list":["post-10549","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-stomach-and-small-bowel","tag-bladder-cancer","tag-ranitidine","tag-stomach-2"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/10549","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=10549"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=10549"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=10549"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}