The \u201cother\u201d cancers in Lynch syndrome include small-bowel, pancreatobiliary, urinary tract, and brain cancers, as well as sebaceous neoplasms. Routine screening for many of these cancer types is often not performed unless there is a family history of the particular cancer type.<\/p>\n\n\n\n
In an analysis of 2 cohorts that included a total of more than 4400 carriers of Lynch syndrome, multivariable analysis of age, sex, mutation, and family history was used to determine whether a family history of other cancers indeed predicts the risk of those same cancers in patients with Lynch syndrome. <\/p>\n\n\n\n
In the larger cohort of 3800 patients, male sex was associated with colorectal cancer (CRC; odds ratio [OR], 4.8), urinary tract cancer (OR, 1.9), small-bowel cancer (OR, 3.8), sebaceous neoplasms (OR, 1.8), and gastric cancer (OR, 3.0). MLH1<\/em> (relative to MSH6<\/em> or PMS2<\/em>) was associated with CRC (OR, 3.7) and gastric cancer (OR, 6.6). MSH2<\/em> was associated with CRC (OR, 1.8), gastric cancer (OR, 5.2), urinary tract cancer (OR, 4.0), small-bowel cancer (OR, 2.5), and sebaceous neoplasms (OR, 4.3). Familial history of cancer (OR per affected first- or second-degree relative) was associated with the same type of cancer in patients with Lynch syndrome for endometrial (OR, 1.4), ovarian (OR, 1.3), urinary tract (OR, 2.7), small-bowel (OR, 3.2), gastric (OR, 1.9), and pancreatobiliary cancers (OR, 2.1) and sebaceous neoplasms (OR, 7.4).<\/p>\n","protected":false},"excerpt":{"rendered":" The \u201cother\u201d cancers in Lynch syndrome include small-bowel, pancreatobiliary, urinary tract, and brain cancers, as well as sebaceous neoplasms. Routine screening for many of these cancer types is often not performed unless there is a family history of the particular cancer type. In an analysis of 2 cohorts that included a total of more than … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1769],"tags":[2058,2024,1861],"class_list":["post-10403","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-asge-kolon","tag-colon-2","tag-family-history","tag-lynch-syndrome"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/10403","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=10403"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=10403"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=10403"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}