{"id":10384,"date":"2021-04-29T17:42:09","date_gmt":"2021-04-29T15:42:09","guid":{"rendered":"https:\/\/www.endoscopy-campus.com\/?post_type=ec-news&#038;p=10384"},"modified":"2021-04-29T17:42:10","modified_gmt":"2021-04-29T15:42:10","slug":"modeling-suggests-later-starting-age-and-3-year-intervals-for-colonoscopy-in-msh6-and-pms2","status":"publish","type":"ec-news","link":"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/modeling-suggests-later-starting-age-and-3-year-intervals-for-colonoscopy-in-msh6-and-pms2\/","title":{"rendered":"Modeling Suggests Later Starting Age and 3-Year Intervals for Colonoscopy in MSH6 and PMS2"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Lynch syndrome is associated with increased cancer risk, particularly in the colorectum, as a result of germline mutations in any of 4 mismatch repair genes designated<em>&nbsp;MLH1<\/em>,&nbsp;<em>MSH2<\/em>,&nbsp;<em>MSH6<\/em>, and&nbsp;<em>PMS2<\/em>. The risk of colorectal cancer is lower in&nbsp;<em>MSH6<\/em>&nbsp;and&nbsp;<em>PMS2<\/em>&nbsp;compared to&nbsp;<em>MLH1<\/em>&nbsp;and&nbsp;<em>MSH2<\/em>.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In a modeling study, the optimal surveillance strategy for each mismatch repair gene was annually beginning at age 25 for&nbsp;<em>MLH1<\/em>, biennially from age 25 for&nbsp;<em>MSH2<\/em>, every 3 years starting at age 35 for&nbsp;<em>MSH6<\/em>, and every 3 years beginning at age 40 for&nbsp;<em>PMS2<\/em>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lynch syndrome is associated with increased cancer risk, particularly in the colorectum, as a result of germline mutations in any of 4 mismatch repair genes designated&nbsp;MLH1,&nbsp;MSH2,&nbsp;MSH6, and&nbsp;PMS2. The risk of colorectal cancer is lower in&nbsp;MSH6&nbsp;and&nbsp;PMS2&nbsp;compared to&nbsp;MLH1&nbsp;and&nbsp;MSH2.&nbsp; In a modeling study, the optimal surveillance strategy for each mismatch repair gene was annually beginning at age 25 &#8230; <a title=\"Modeling Suggests Later Starting Age and 3-Year Intervals for Colonoscopy in MSH6 and PMS2\" class=\"read-more\" href=\"https:\/\/www.endoscopy-campus.com\/en\/ec-news\/modeling-suggests-later-starting-age-and-3-year-intervals-for-colonoscopy-in-msh6-and-pms2\/\" aria-label=\"Read more about Modeling Suggests Later Starting Age and 3-Year Intervals for Colonoscopy in MSH6 and PMS2\">Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,1769],"tags":[2722,2723],"class_list":["post-10384","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-asge-kolon","tag-msh6","tag-pms2"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/10384","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=10384"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=10384"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=10384"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}