The optimal treatment for cholangiocarcinoma (CCA) or ampullary carcinoma (AC) is surgery. When deemed unresectable and not amenable to neoadjuvant therapy followed by liver transplantation, endoscopic placement of stents plus radiation and\/or chemotherapy are common uses for palliation. <\/p>\n\n\n\n
In this randomized controlled trial, investigators at 3 centers compared overall survival (OS) among 174 patients with extrahepatic CCA (excluding Bismuth Type IV) or AC. The patients were randomly selected for treatment with either stent placement alone (ST Only, n=87) versus stent placement with endoscopic bipolar radiofrequency ablation (RFA, n=87). Dual interventions were performed 3 months apart. <\/p>\n\n\n\n
Although there were no significant differences in control of jaundice or stent patency, the RFA group experienced significantly prolonged OS (14.3 vs 9.2 months; hazard ratio, 0.488; 95% confidence interval, 0.351-0.678; P<\/em><.001) and significantly better postprocedural Karnofsky performance scores for 9 months (all P<\/em><.001), according to Kaplan-Meier analysis. The survival benefit was present for hilar CCA (P<\/em>=.004), distal CCA (P<\/em>=.038), and AC (P<\/em>+.032). Overall adverse events were comparable (27.6% [RFA] vs 19.5% [ST Only], P<\/em>=.211), but acute cholecystitis was more common in the RFA group (9 vs 0, P<\/em>=.003).<\/p>\n","protected":false},"excerpt":{"rendered":" The optimal treatment for cholangiocarcinoma (CCA) or ampullary carcinoma (AC) is surgery. When deemed unresectable and not amenable to neoadjuvant therapy followed by liver transplantation, endoscopic placement of stents plus radiation and\/or chemotherapy are common uses for palliation. In this randomized controlled trial, investigators at 3 centers compared overall survival (OS) among 174 patients with … Read more<\/a><\/p>\n","protected":false},"template":"","categories":[1768,67],"tags":[2128,2691,1040,2692],"class_list":["post-10151","ec-news","type-ec-news","status-publish","hentry","category-asge-journal-scan","category-bauchspeicheldruese-pankreas","tag-pancreatobiliary","tag-radiofrequency-ablation-2","tag-rfa","tag-stent-placement"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news\/10151","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-news"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/ec-news"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=10151"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=10151"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=10151"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}