{"id":5293,"date":"2019-05-16T13:06:52","date_gmt":"2019-05-16T11:06:52","guid":{"rendered":"https:\/\/www.endoscopy-campus.com\/bildergalerie\/invasive-amoebiasis-im-kolon\/"},"modified":"2019-09-17T14:00:19","modified_gmt":"2019-09-17T12:00:19","slug":"invasive-amebiasis-in-the-colon","status":"publish","type":"bildergalerie","link":"https:\/\/www.endoscopy-campus.com\/en\/bildergalerie\/invasive-amebiasis-in-the-colon\/","title":{"rendered":"Invasive amebiasis in the colon"},"content":{"rendered":"\n

Dr. Ulrike Schempf and Dr. D\u00f6rte Wichmann
Interdisciplinary Endoscopy Unit, T\u00fcbingen University Hospital <\/p>\n\n\n\n

\n\n\n\n

Patient history, clinical findings?<\/h3>\n\n\n\n

A 73-year-old man presented in otherwise good general condition, reporting recurrent bouts of fever and right-sided abdominal pain over the few previous days. The patient\u2019s history showed that he had been in India a few months before this event, where he had contracted a feverish diarrheal infection.<\/p>\n\n\n\n

Laboratory<\/h3>\n\n\n\n

There was a pattern of acute inflammation with 17210 leukocytes\/\u00b5L and a CRP of 6.7 mg\/dL. AP was slightly raised at 162 U\/L, ?GT was raised at 219, and the bilirubin level was normal. A complete blood count showed raised monocytes (11070\/\u00b5L) and neutrophils (13180\/\u00b5L). <\/p>\n\n\n\n

Imaging<\/h3>\n\n\n\n
\"\"<\/figure>
\n

Following hospital admission, CT of the abdomen and pelvis revealed a large, hypodense lesion in the right hepatic area, with contrast uptake at its edges and liquid mean density values (Fig. 1). As the patient was in severe pain and in view of the size of the lesion, drainage was carried out on suspicion of a hepatic abscess. A putrid secretion was aspirated.<\/p>\n<\/div><\/div>\n\n\n\n

Fig. 1: Angio-CT of the epigastric region, with a large hepatic abscess <\/p>\n\n\n\n

<\/div>\n\n\n\n

Microbiology<\/h3>\n\n\n\n

The serology findings were positive for Entamoeba histolytica IgG. The fecal samples initially taken to test for E. histolytica were negative.<\/p>\n\n\n\n

Course<\/h3>\n\n\n\n

Three days after placement of the abscess drain, the patient developed Hb-relevant and circulation-relevant lower gastrointestinal bleeding. Images from the emergency colonoscopy are shown in Figs. 2\u20134. Several ulcerations without acute bleeding stigmata were detected in the ascending colon in the immediate vicinity of the ileocecal valve. The terminal ileum had no ulcerations and was free of blood. The repeat fecal samples then taken were positive for E. histolytica (with evidence of cysts in the feces).<\/p>\n\n\n\n

Endoscopy<\/h3>\n\n\n\n
\"\"
Fig. 2: Colonoscopy findings: view from the ascending colon toward the cecum<\/figcaption><\/figure><\/div>\n\n\n\n
\"\"
Fig. 3: View from the ascending colon toward the fold with the ileocecal valve.<\/figcaption><\/figure><\/div>\n\n\n\n
\"\"
Fig. 4: A large ulcer in the proximal ascending colon<\/figcaption><\/figure><\/div>\n\n\n\n

Summary<\/h3>\n\n\n\n

The patient had contracted invasive amebiasis.<\/p>\n\n\n\n

Interesting facts about amebiasis:<\/strong><\/h3>\n\n\n\n

Pathogen<\/h4>\n\n\n\n

The parasite Entamoeba histolytica, an intestinal protozoon, trophozoite (vegetative, not infectious) or cystiform (large or minute form, infectious, sometimes invasive).<\/p>\n\n\n\n

Transmission\/infection <\/h4>\n\n\n\n

contaminated food<\/p>\n\n\n\n

Incidence<\/h4>\n\n\n\n

tropical and subtropical regions<\/p>\n\n\n\n

Course:<\/h4>\n\n\n\n
  1. Asymptomatic course (90% of cases); affected individuals are symptom-free carriers.<\/li>
  2. Invasive amebiasis; development of ulcerations and intestinal abscesses; typical finding: feces with raspberry jelly appearance. <\/li>
  3. Extraintestinal amebiasis; abscess formation in the liver (95%) or other organs. <\/li><\/ol>\n\n\n\n

    Frequency<\/h4>\n\n\n\n

    the WHO estimates the annual numbers of incident cases at 50,000, with up to 110,000 deaths per year.<\/p>\n\n\n\n

    Mortality<\/h4>\n\n\n\n

    Approximately 1% <\/p>\n\n\n\n

    Treatment<\/h4>\n\n\n\n

    Intravenous or oral metronidazole in cases of invasive amebiasis persisting for more than 10 days, and in case of intestinal infection one-stage or two-stage eradication with paromomycin 3 \u00d7 500 mg\/d for 10 days.<\/p>\n\n\n\n

    Reference<\/h3>\n\n\n\n

    Deutsche Gesellschaft f\u00fcr Tropenmedizin und Internationale Gesundheit. S1-Leitlinie Diagnostik und Therapie der Am\u00f6biasis. \u00dcberarbeite Version Oktober 2018. Berlin: Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF), 2018. Available at: https:\/\/www.awmf.org\/leitlinien\/detail\/ll\/042-002.html (accessed 29 May 2019).<\/p>\n","protected":false},"excerpt":{"rendered":"

    Invasive amebiasis in the colon, with ulcerations in the right colon.<\/p>\n","protected":false},"featured_media":5283,"template":"","categories":[97,171],"tags":[1760,1758,1759,82],"ec-magazin-ausgaben":[1788],"sponsoren-erwaehnung":[],"autor":[],"class_list":["post-5293","bildergalerie","type-bildergalerie","status-publish","has-post-thumbnail","hentry","category-literature","category-special-cases","tag-amebiasis","tag-amoebiasis","tag-amoebiasis-en","tag-colon","ec-magazin-ausgaben-ec-magazine-2019-02"],"_links":{"self":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/bildergalerie\/5293","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/bildergalerie"}],"about":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/types\/bildergalerie"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media\/5283"}],"wp:attachment":[{"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/media?parent=5293"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/categories?post=5293"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/tags?post=5293"},{"taxonomy":"ec-magazin-ausgaben","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/ec-magazin-ausgaben?post=5293"},{"taxonomy":"sponsoren-erwaehnung","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/sponsoren-erwaehnung?post=5293"},{"taxonomy":"autor","embeddable":true,"href":"https:\/\/www.endoscopy-campus.com\/en\/wp-json\/wp\/v2\/autor?post=5293"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}