Colonoscopy Every 10 Years Starting at Age 40 Modeled as Cost-Effective for Men With Body Mass Index ≥35
Douglas K. Rex, MD, MASGE, reviewing Yeoh A, et al. Clin Gastroenterol Hepatol 2022 Aug 4.
Obesity is a known risk factor for colorectal cancer (CRC) in both men and women. A previously developed decision analytic was used to model the cost-effectiveness of performing colonoscopy every 5 or 10 years or fecal immunochemical test (FIT) screening every year in overweight and obese individuals, beginning at age 40, 45, or 50 through age 75, with 100% adherence.
Colonoscopy starting at age 45 or FIT starting at 40 was cost-effective using a threshold of $100,000 per quality-adjusted life year (QALY) gained for all body mass index (BMI) groups and both sexes. Colonoscopy every 10 years was always preferred over colonoscopy every 5 years.
Colonoscopy every 10 years starting at age 40 was cost-effective for men with BMI ≥35, with $93,300 per QALY for BMI 35 to <40 and $80,400 per QALY for BMI ≥40.
Note to readers: At the time we reviewed this paper, its publisher noted that it was not in final form and that subsequent changes might be made.
Yeoh A, Mannalithara A, Ladabaum U. Cost-effectiveness of earlier or more intensive colorectal cancer screening in overweight and obese patients. Clin Gastroenterol Hepatol 2022 Aug 4. (Epub ahead of print) (https://doi.org/10.1016/j.cgh.2022.07.028)